Ozone increases atrial natriuretic peptides in heart, lung and circulation of aged vs. adult animals.
Ozone increases atrial natriuretic peptides in heart, lung and circulation of aged vs. adult animals.
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与成年动物相比，臭氧可增加老年动物心脏、肺和循环中的心房钠尿肽。
DOI：
10.1159/000213590
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发表时间：
1994
期刊：
影响因子：
3.5
通讯作者：
Montgomery,MR
中科院分区：
文献类型：
--
作者：
Vesely,DL;Giordano,AT;Raska-Emery,P;Montgomery,MR
臭氧可导致肺水肿，同时降低血压。心房利钠肽可能介导这两种作用，因为它们增加肺毛细血管通透性，是有效的血管舒张肽。为了检查这种可能性并确定老年动物对臭氧的反应是否不同，将成年（4-6个月大）和老年（24-26个月大）Fischer 344大鼠暴露于臭氧（百万分之0.5）8小时。臭氧使肺中前心钠素1-30、前心钠素31-67和心钠素（ANF）放射免疫测定识别的心钠素分别从3.7 ± 0.2、3.5 ± 0.1和3.0 ± 0.2 ng/g肺增加到9.7 ± 1.0、9.2 ± 0.4、老年大鼠肺组织中的含量分别从3.6 ± 0.1、3.5 ± 0.1和3.2 ± 0.1 ng/g增加到10.2 ± 0.3、10.0 ± 0.2和12.6 ± 0.2 ng/g。臭氧使心脏中这些肽的含量增加了2至5倍，从266 ± 25，226 ± 22和288 ± 40 ng/g心脏增加到716 ± 26，471 ± 14和1，473 ± 235 ng/g，从495 ± 17，483 ± 22，老龄动物心脏分别为501 ± 18、903 ± 16、879 ± 21和1,489 ± 31 ng/g。臭氧还使循环系统中这些心房利钠肽的浓度加倍。这项研究表明，臭氧增加心房利钠肽在肺，心脏和循环中的老年人与成年动物相同的幅度，表明臭氧老化的同等反应。这项研究进一步表明，心房利钠肽可能介导的血压下降和肺水肿观察臭氧暴露。
Ozone can cause pulmonary edema and simultaneously decrease blood pressure. Atrial natriuretic peptides may mediate both of these affects since they increase pulmonary capillary permeability and are potent vasodilating peptides. To examine this possibility and determine if aged animals respond differently to ozone, adult (4-6 months old) and aged (24-26 months old) Fischer 344 rats were exposed to ozone (0.5 parts per million) for 8 h. Ozone increased atrial natriuretic peptides recognized by the proANF 1-30, proANF 31-67, and atrial natriuretic factor (ANF) radioimmunoassays in lung from 3.7 ± 0.2, 3.5 ± 0.1, and 3.0 ± 0.2 ng/g of lung, respectively, to 9.7 ± 1.0, 9.2 ± 0.4, and 13.3 ± 2.7 ng/g in adult rats (n = 6) and from 3.6 ± 0.1,3.5 ± 0.1, and 3.2 ± 0.1 ng/g of lung of aged rats (n = 6) to 10.2 ± 0.3, 10.0 ± 0.2, and 12.6 ± 0.2 ng/g. Ozone increased the content of these peptides in the heart 2- to 5-fold from 266 ± 25, 226 ± 22, and 288 ± 40 ng/g of heart to 716 ± 26,471 ± 14, and 1,473 ± 235 ng/g in the same adult animals and from 495 ± 17, 483 ± 22, and 501 ± 18 ng/g to 903 ± 16,879 ± 21, and 1,489 ± 31 ng/g of heart in the aged animals. Ozone also doubled the concentration of these atrial natriuretic peptides in the circulatory system. This study demonstrates that ozone increases atrial natriuretic peptides in the lung, heart, and circulation of equal magnitude in aged versus adult animals, indicating an equal response to ozone with aging. This study further suggests that atrial natriuretic peptides may mediate the decreased blood pressure and pulmonary edema observed with ozone exposure.