Paraquat toxicity is enhanced by iron and reduced by desferrioxamine in laboratory mice.
Paraquat toxicity is enhanced by iron and reduced by desferrioxamine in laboratory mice.
复制标题
在实验室小鼠中，铁会增强百草枯的毒性，而去铁敏则可降低百草枯的毒性。
DOI：
10.1016/0006-2952(85)90659-8
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发表时间：
1985
影响因子：
5.8
通讯作者：
M. Chevion
中科院分区：
文献类型：
--
作者：
R. Kohen;M. Chevion
去铁胺是一种特异性铁螯合剂[1，2]，临床上用于治疗铁过载[3，4]，成功地提高了百草枯中毒实验室小鼠的存活率。另一方面，在中毒前给小鼠补充铁会导致它们的寿命严重缩短。百草枯（甲基紫精; 1，1 '-二甲基-4，4'-联吡啶（阳离子），二氯化物; PQ）是一种广泛使用的除草剂[5，6]。自六十年代初，当它的使用在世界各地蔓延，数百例百草枯中毒死亡的报告[% 9]。这促使人们使用动物研究和其他模型进行广泛的研究，包括体内和体外研究。使用细菌系统的研究表明，百草枯毒性的表现需要分子氧和易于代谢的电子源[10，11]。然而，尽管进行了大量研究，但百草枯对哺乳动物毒性的确切机制仍未完全了解[12]。众所周知，百草枯通过肺损伤引起毒性[13]，无论接触方法如何[14]。百草枯中毒的临床表现包括肺水肿（含水量较高）[15]、肺纤维化和肺酶活性变化[16]，所有这些都导致死亡。
Desferrioxamine, a specific iron chelator [1, 2] used clinically to treat cases of iron overload [3, 4], successfully increased the survival of laboratory mice poisoned by paraquat. On the other hand, loading the mice with iron prior to the poisoning led to a severe reduction in their life span. We therefore conclude that iron plays a major role in paraquat toxicity.Paraquat (methyl viologen; 1, 1'-dimethyl-4, 4'-bipyridinium (cation), di-chloride; PQ) is a widely used herbicide [5, 6]. Since the early sixties, when its use spread all over the world, hundreds of cases of death from paraquat poisoning have been reported [% 9]. This has prompted extensive research using animal studies and other models, both in vivo and in vitro. Using bacterial systems, it has been shown that the manifestation of paraquat toxicity requires molecular oxygen and a readily metabolizable electron source [10, 11]. However, despite voluminous research, the exact mechanisms of paraquat toxicity in mammals is still not fully understood [12]. It is known that paraquat causes its toxicity through a pulmonary injury [13], regardless of the method of contact [14]. Clinical manifestations of paraquat toxicity include edema (higher water content) of the lungs [15], fibrosis of the lungs, and change in activity of lung enzymes [16], all leading to mortality.