An unusual nitrogenous terphenyl derivative from fruiting bodies of the basidiomycete Sarcodon leucopus
An unusual nitrogenous terphenyl derivative from fruiting bodies of the basidiomycete Sarcodon leucopus
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DOI：
10.1021/np990293d
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发表时间：
2000-03-01
影响因子：
5.1
通讯作者：
Tringali, C
中科院分区：
文献类型：
--
作者：
Geraci, C;Neri, P;Tringali, C
一种新的含氮代谢物sarcodonin(3)从担子菌Sarcodon leucopus子实体中分离得到。通过使用一系列光谱技术（包括N-15核磁共振、梯度增强和反向检测二维核磁共振实验）和化学降解，对其过乙酸酯4进行了仔细研究，确定了3的结构。ROESY数据和分子力学（MM+）计算得出了4的绝对构型。化合物3对KB和P-388肿瘤细胞具有中等的细胞毒性。
A new nitrogenous metabolite with a p-terphenyl core, sarcodonin (3), has been isolated from fruiting bodies of the basidiomycete Sarcodon leucopus. The structure of 3 was determined through a careful study of its peracetate 4, by use of an array of spectroscopic techniques (including N-15 NMR, gradient-enhanced, and reverse-detected 2D NMR experiments) and chemical degradation. ROESY data and molecular mechanics (MM+) calculations led to assignment of the absolute configuration of 4. Compound 3 exhibited moderate cytotoxicity against KB and P-388 tumor cell cultures.