Donor-derived Viral Infections in Liver Transplantation.
Donor-derived Viral Infections in Liver Transplantation.
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DOI：
10.1097/tp.0000000000002326
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发表时间：
2018-11
期刊：
影响因子：
6.2
通讯作者：
Ison MG
中科院分区：
文献类型：
--
作者：
Nam H;Nilles KM;Levitsky J;Ison MG
供体源性感染被定义为存在于供体中并传播给 1 个或多个受体的任何感染。供体源性感染可分为两类：“预期”和“意外”感染。当已知捐献者患有感染时，例如捐献时巨细胞病毒、EB 病毒或乙型肝炎核心抗体血清学呈阳性，就会发生预期传播。当捐献者在捐献前没有已知的感染，但一名或多名移植受者出现来自共同捐献者的感染时，就会发生意外传播。据估计，实体器官移植受者中发生意外感染的比例远低于 1%。我们将回顾肝移植中供体源性病毒传染病传播的流行病学、危险因素以及预防和管理方法。
Donor-derived infections are defined as any infection present in the donor that is transmitted to 1 or more recipients. Donor-derived infections can be categorized into 2 groups: “expected” and “unexpected” infections. Expected transmissions occur when the donor is known to have an infection, such as positive serology for cytomegalovirus, Epstein Barr virus, or hepatitis B core antibody, at the time of donation. Unexpected transmissions occur when a donor has no known infection before donation, but 1 or more transplant recipients develop an infection derived from the common donor. Unexpected infections are estimated to occur in far less than 1% of solid organ transplant recipients. We will review the epidemiology, risk factors, and approaches to prevention and management of donor-derived viral infectious disease transmission in liver transplantation.