Description of three data sets: Collaborative study on the genetics of asthma (CSGA), the German affected sib-pair study, and the Hutterites of South Dakota
Description of three data sets: Collaborative study on the genetics of asthma (CSGA), the German affected sib-pair study, and the Hutterites of South Dakota
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DOI：
10.1002/gepi.2001.21.s1.s4
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发表时间：
2001-01-01
影响因子：
2.1
通讯作者：
Ober, C
中科院分区：
文献类型：
--
作者：
Meyers, DA;Wjst, M;Ober, C
三个不同的数据集（包含来自全基因组筛选的临床数据和标记）已提交给第 12 届遗传分析研讨会进行分析。在每项研究中，都对参与者的哮喘和相关表型进行了仔细的表征。使用醋甲胆碱和标准化方案进行支气管高反应性测试。使用标准化技术测量总血清 IgE 水平。此外，还获得了类似的症状和相关环境暴露的问卷数据。提交了用于每个全基因组筛选的多态性标记的相关临床数据和基因型。美国哮喘遗传学合作研究的数据集代表了由白人和非裔美国人家庭组成的异质人群，通过来自多个中心的两个患有临床哮喘的兄弟姐妹确定。同样，德国哮喘遗传学小组的家庭也通过多个中心患有哮喘的两个兄弟姐妹进行了确定。与这些数据集相反，卡罗尔·奥伯博士和她的合作者提交了来自南达科他州近交哈特派人口的数据。 (C) 2001 Wiley-Liss, Inc.
Three different data sets with clinical data and markers from genome-wide screens were submitted for analysis at Genetic Analysis Workshop 12. In each study, participants were carefully characterized for asthma and related phenotypes. Testing for bronchial hyper-responsiveness using methacholine and standardized protocols was performed. Total serum IgE levels were measured using standardized techniques. In addition, similar questionnaire data on symptoms and relevant environmental exposures were obtained. Relevant clinical data and genotypes for the polymorphic markers used for each genome-wide screen were submitted. The data set from the United States Collaborative Study on the Genetics of Asthma represents a heterogeneous population consisting of both Caucasian and African American families ascertained through two siblings with clinical asthma from multiple centers. Likewise, the families from the German Asthma Genetics Group were also ascertained through two siblings with asthma at multiple centers. In a contrast to these data sets, Dr. Carole Ober and her collaborators submitted data from the inbred Hutterite population in South Dakota. (C) 2001 Wiley-Liss, Inc.