Antibodies against glycosylated native MOG are elevated in patients with multiple sclerosis
Antibodies against glycosylated native MOG are elevated in patients with multiple sclerosis
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DOI：
10.1212/01.wnl.0000147259.34163.33
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发表时间：
2004-12-28
期刊：
影响因子：
9.9
通讯作者：
Weissert, R
中科院分区：
文献类型：
--
作者：
Gaertner, S;de Graaf, KL;Weissert, R
用ELISA法检测多发性硬化症（MS）患者和对照组的天然糖基化髓鞘-少突胶质细胞-糖蛋白（MOG）抗体。抗MOG IgM抗体在首次脱髓鞘事件期间升高。与缓解期患者和健康对照组相比，复发期患者和继发性慢性进展性MS患者的MOG特异性IgG抗体更高。抗天然MOG抗体可能是MS的潜在生物标志物。
Antibodies against native glycosylated myelin-oligodendrocyte-glycoprotein (MOG) were measured by ELISA in patients with multiple sclerosis (MS) and controls. Anti-MOG IgM antibodies were elevated during the first demyelinating event. Higher MOG-specific IgG antibodies were found in patients during relapses and in secondary chronic progressive MS compared to patients in remission and healthy controls. Antibodies against native MOG may be a potential biomarker for MS.