Towards a Rational Approach for the Logical Modelling of Inhibition in Metabolic Networks
Towards a Rational Approach for the Logical Modelling of Inhibition in Metabolic Networks
复制标题
代谢网络抑制逻辑建模的合理方法
DOI：
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
O. Ray
中科院分区：
文献类型：
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作者：
O. Ray
本文对代谢网络中抑制的逻辑建模做出了两个贡献。首先，它暴露了现有的国家的最先进的代谢理论的逻辑不一致。然后，它提出了一个新的模型，所需的假设是一致的推断。这项工作的基础是使用非单调逻辑程序来表示和原因竞争抑制作用的净浓度的代谢物在酶催化的生化网络。
This paper makes two contributions towards the logical modelling of inhibition in metabolic networks. First it exposes the logical inconsistency of an existing state-of-the-art metabolic theory. Then it proposes a new model from which the required hypotheses are consistently inferred. Underlying this work is use of nonmonotonic logic programs to represent and reason about competing inhibitory effects on the net concentrations of metabolites in enzyme-catalysed biochemical networks.