Long noncoding RNA HOXD-AS2 regulates cell cycle to promote glioma progression
Long noncoding RNA HOXD-AS2 regulates cell cycle to promote glioma progression
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DOI：
10.1002/jcb.28117
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发表时间：
2019-05-01
影响因子：
4
通讯作者：
Peng, Xiaozhong
中科院分区：
文献类型：
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作者：
Qi, Yingjiao;Wang, Zhixing;Peng, Xiaozhong
现在，许多令人兴奋的发现发现，长非编码RNA（lncRNA）在癌症恶性进展中发挥着至关重要的作用。然而，它们与神经胶质瘤的潜在关系尚不清楚。在这里，我们进行了高通量微阵列来检测神经胶质瘤细胞系和正常星形胶质细胞系之间的lncRNA表达谱。 HOXD-AS2 在神经胶质瘤细胞中增加，与神经胶质瘤分级和不良预后相关。 HOXD-AS2 的缺失可以通过诱导体外细胞周期 G1 停滞来抑制神经胶质瘤细胞的生长。通过敲低 HOXD-AS2 的表达，不仅在皮下注射模型中而且在原位植入模型中抑制了胶质瘤的增殖。这些发现表明 HOXD-AS2 促进神经胶质瘤进展，并可能作为神经胶质瘤诊断和治疗的潜在靶点。
Now, numerous exciting findings have been found that long noncoding RNAs (lncRNAs) play a vital role in cancer malignant progression. However, their potential involvement in glioma is not well understood. Here, we performed a high-throughput microarray to detect the lncRNA expression profiles between glioma cell lines and normal astrocyte cell lines. HOXD-AS2 was increased in glioma cells and it was associated with glioma grade and poor prognosis. Loss of HOXD-AS2 can inhibit glioma cell growth by inducing cell-cycle G1 arrest in vitro. The proliferation of glioma was inhibited followed by knocking down the expression of HOXD-AS2 not only in subcutaneous injection model but also in orthotopic implantation model. These findings indicate that HOXD-AS2 promotes the glioma progression and may serve as a potential target for glioma diagnosis and therapy.