PLASMA NOREPINEPHRINE VARIATIONS WITH DIETARY-SODIUM INTAKE
PLASMA NOREPINEPHRINE VARIATIONS WITH DIETARY-SODIUM INTAKE
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DOI：
10.1161/01.hyp.2.1.29
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发表时间：
1980-01-01
期刊：
影响因子：
8.3
通讯作者：
GREENHOUSE, J
中科院分区：
文献类型：
--
作者：
NICHOLLS, MG;KIOWSKI, W;GREENHOUSE, J
在20名正常男性志愿者中，测量了一系列饮食钠摄入量（10-300 meq[当量]/天）的血浆儿茶酚胺和肾素活性水平，作为以后与高血压患者进行比较的基线。仰卧位血浆去甲肾上腺素水平呈三相模式，尿钠，而肾上腺素水平没有显着改变钠摄入量，和肾素显示出众所周知的双曲线关系尿钠排泄。最高仰卧位去甲肾上腺素值发生在低盐摄入量，最低时，钠排泄量为100-180 meq/天，和中间时，钠排泄量大于180 meq/天。钠摄入量显然是解释血浆去甲肾上腺素水平的重要考虑因素。
Plasma catecholamine and renin activity levels were measured across a range of dietary Na intakes (10-300 meq[equivalent]/day) in 20 normal male volunteers, as a baseline for later comparison with hypertensive patients. Supine plasma norepinephrine levels presented a triphasic pattern in relation to urine Na, whereas epinephrine levels were not significantly altered by Na intake, and renin showed the well-known hyperbolic relationship to urine Na excretion. Highest supine norepinephrine values occurred at low salt intakes, the lowest when Na excretion was from 100-180 meq/day, and intermediate when Na excretion was greater than 180 meq/day. Na intake is evidently an important consideration in the interpretation of plasma norepinephrine levels.