Effects of resistance training on the inflammatory response.
Effects of resistance training on the inflammatory response.
复制标题
DOI：
10.4162/nrp.2010.4.4.259
复制
发表时间：
2010-08
影响因子：
2.4
通讯作者：
Fernandez ML
中科院分区：
文献类型：
--
作者：
Calle MC;Fernandez ML
阻力训练 (RT) 可以降低心血管疾病和 2 型糖尿病等低度炎症相关疾病的风险。研究细胞因子和运动的大部分数据来自耐力运动。相比之下，建立放疗与炎症之间关系的证据则更为有限。本综述重点关注急性放疗后和慢性放疗后的细胞因子反应。此外，还回顾了放疗对低度全身炎症（例如有 2 型糖尿病风险的个体）的影响。细胞因子是影响免疫细胞和其他器官系统的存活、增殖和分化的分泌蛋白。细胞因子起到细胞内信号的作用，体内几乎所有细胞都分泌细胞因子或具有细胞因子受体。因此，了解细胞因子在特定生理情况（例如放疗）中的作用可能非常复杂。长期放疗的总体效果似乎可以改善炎症，但对炎症细胞因子、肿瘤坏死因子α的具体效果尚不清楚，需要进一步研究。此外，区分慢性和急性白细胞介素 6 水平及其来源也至关重要。 RT 的强度和训练方案的特征可能会产生单一的细胞因子反应，从而导致对运动的不同适应。健康人群的放疗领域需要更多的研究，特别是整理性别和年龄的放疗急性反应。更重要的是，需要对患有低度全身炎症相关疾病的高风险肥胖个体进行研究。确保遵守 RT 计划对于在克服首次急性 RT 反应后获得益处至关重要。因此，放疗可能是预防和延缓低度全身炎症相关疾病的有效方法。
Resistance training (RT) is associated with reduced risk of low grade inflammation related diseases, such as cardiovascular disease and type 2 diabetes. The majority of the data studying cytokines and exercise comes from endurance exercise. In contrast, evidence establishing a relationship between RT and inflammation is more limited. This review focuses on the cytokine responses both following an acute bout, and after chronic RT. In addition, the effect of RT on low grade systemic inflammation such as individuals at risk for type 2 diabetes is reviewed. Cytokines are secreted proteins that influence the survival, proliferation, and differentiation of immune cells and other organ systems. Cytokines function as intracellular signals and almost all cells in the body either secrete them or have cytokine receptors. Thus, understanding cytokine role in a specific physiological situation such as a bout of RT can be exceedingly complex. The overall effect of long term RT appears to ameliorate inflammation, but the specific effects on the inflammatory cytokine, tumor necrosis factor alpha are not clear, requiring further research. Furthermore, it is critical to differentiate between chronically and acute Interleukin-6 levels and its sources. The intensity of the RT and the characteristics of the training protocol may exert singular cytokine responses and as a result different adaptations to exercise. More research is needed in the area of RT in healthy populations, specifically sorting out gender and age RT acute responses. More importantly, studies are needed in obese individuals who are at high risk of developing low grade systemic inflammatory related diseases. Assuring adherence to the RT program is essential to get the benefits after overcoming the first acute RT responses. Hence RT could be an effective way to prevent, and delay low grade systemic inflammatory related diseases.