The structure of the satellite cells in skeletal muscle.
The structure of the satellite cells in skeletal muscle.
复制标题
骨骼肌卫星细胞的结构。
作者：
By R. B. Muir;A. H. Al;David Allbrook;Departmtient
单个骨骼肌纤维的鞘所包围的众多细胞核通常被认为都包含在长肌细胞的肌浆内。然而，Mauro（1961）指出，这些细胞核中的一部分属于小的独立细胞，在他的初步通讯中，这些细胞被称为“卫星细胞”。AMauro指出，这些离散的梭形细胞位于肌膜基底膜成分的内表面，存在于青蛙的胫骨前肌、缝匠肌和髂腓肌以及白色大鼠的缝匠肌和胫骨前肌中。通过对另外两种脊椎动物，果蝠和白色小鼠肌肉的研究，现在对这些卫星细胞的分布和细胞学结构有了更详细的描述。提出了由于单电子显微镜切片不能排除肌纤维细胞质及其卫星细胞之间存在有限的连续区域，因此使用实验方法来表明这些细胞是独立的。本文还讨论了卫星细胞在肌肉再生和骨骼肌组织培养中的作用。
The numerous nuclei enclosed by the sheath of a single skeletal muscle fibre are usually all considered to be contained within the sarcoplasm of the long muscle cell. Mauro (1961) shows, however, that a proportion of these nuclei belong to small separate cells, which in his preliminary communication are designated 'satellite cells'. These discrete, fusiform cells, applied to the inner surface of the basement membrane component of the sarcolemma, are stated by AMauro to be present in the tibialis anterior, sartorius and iliofibularis muscles of the frog and in the sartorius and tibialis anterior muscles of the white rat. From studies on the muscles of two other vertebrates, the fruit bat and white mouse, a more detailed description of the distribution and cytological structure of these satellite cells is now. presented. Since single electron microscope sections cannot exclude the presence of limited areas of continuity between the cytoplasm of the muscle fibre and its satellite cells, an experimental method is used to show that these cells are osmotically independent. The possible roles of the satellite cells in muscle regeneration and in the establishment of tissue culture preparations of skeletal muscle are discussed.