Intrinsic circadian clock of the mammalian retina: Importance for retinal processing of visual information
Intrinsic circadian clock of the mammalian retina: Importance for retinal processing of visual information
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DOI：
10.1016/j.cell.2007.06.045
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发表时间：
2007-08-24
期刊：
影响因子：
64.5
通讯作者：
Weitz, Charles J.
中科院分区：
文献类型：
--
作者：
Storch, Kai-Florian;Paz, Carlos;Weitz, Charles J.
生物钟在哺乳动物组织中广泛分布，但对大脑视交叉上核以外的生物钟的生理功能知之甚少。视网膜有一个内在的生物钟，但它对视力的重要性尚不清楚。在这里，我们发现缺乏Bmal1（生物钟功能所需的基因）的小鼠对光有异常的视网膜转录反应和对光有缺陷的视网膜内电反应，但光感受器对光的正常反应和视网膜在光学和电子显微镜下结构正常。我们培育了具有视网膜特异性Bmal1基因缺失的小鼠，它们的视网膜视觉生理缺陷与所有组织中缺乏Bmal1的小鼠基本相同，并且缺乏视网膜内对光电反应的昼夜节律。我们的研究结果表明，视网膜的内在生物钟在体内调节视网膜的视觉处理。
Circadian clocks are widely distributed in mammalian tissues, but little is known about the physiological functions of clocks outside the suprachiasmatic nucleus of the brain. The retina has an intrinsic circadian clock, but its importance for vision is unknown. Here we show that mice lacking Bmal1, a gene required for clock function, had abnormal retinal transcriptional responses to light and defective inner retinal electrical responses to light, but normal photoreceptor responses to light and retinas that appeared structurally normal by light and electron microscopy. We generated mice with a retina-specific genetic deletion of Bmal1, and they had defects of retinal visual physiology essentially identical to those of mice lacking Bmal1 in all tissues and lacked a circadian rhythm of inner retinal electrical responses to light. Our findings indicate that the intrinsic circadian clock of the retina regulates retinal visual processing in vivo.