Whole-grain foods do not affect insulin sensitivity or markers of lipid peroxidation and inflammation in healthy, moderately overweight subjects
Whole-grain foods do not affect insulin sensitivity or markers of lipid peroxidation and inflammation in healthy, moderately overweight subjects
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DOI：
10.1093/jn/137.6.1401
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发表时间：
2007-06-01
影响因子：
4.2
通讯作者：
Vessby, Bengt
中科院分区：
文献类型：
--
作者：
Andersson, Agneta;Tengblad, Siv;Vessby, Bengt
全谷物食品的高摄入量与冠心病和2型糖尿病的发病率呈负相关，但其机制仍不清楚。我们的研究旨在评估富含全谷物的饮食与含有相同数量精制谷物的饮食对胰岛素敏感性和脂质过氧化和炎症标志物的影响。在一项随机交叉研究中，22名女性和8名男性（BMI 28 +/- 2）被给予全谷物或精制谷物产品（3片面包片，2片脆面包片，1份牛奶什锦早餐和1份意大利面），包括在他们的习惯性日常饮食中，持续两个6周。正常血糖高胰岛素钳夹试验测定外周胰岛素敏感性。8-异前列腺素F-2 α（8-iso PGF（2 α）），一种F-2-异前列烷，在尿液中测定作为脂质过氧化的标志物，并在血浆中分析高度敏感的C-反应蛋白和IL-6作为炎症的标志物。当受试者食用全麦产品时，外周胰岛素敏感性[mg葡萄糖中心点kg体重（-1）中心点min（-1）/单位血浆胰岛素（mU/L）× 100]没有改善（基线时为6.8 ± 3.0，6周后为6.5 ± 2.7）或精制产品（分别为6.4 ± 2.9和6.9 ± 3.2），两个阶段之间无差异。全谷物消费也没有影响尿液中的8-iso-PGF（2 α），血浆中的IL-6和C-反应蛋白，血压或血脂浓度。总之，在6周的健康中度超重成年人的日常习惯饮食中，用全谷物（主要是碾磨小麦）代替精制谷物产品并不影响胰岛素敏感性或脂质过氧化和炎症标志物。
High intakes of whole grain foods are inversely related to the incidence of coronary heart diseases and type 2 diabetes, but the mechanisms remain unclear. Our study aimed to evaluate the effects of a diet rich in whole grains compared with a diet containing the same amount of refined grains on insulin sensitivity and markers of lipid peroxidation and inflammation. In a randomized crossover study, 22 women and 8 men (BMI 28 +/- 2) were given either whole-grain or refined-grain products (3 bread slices, 2 crisp bread slices, 1 portion muesli, and 1 portion pasta) to include in their habitual daily diet for two 6-wk periods. Peripheral insulin sensitivity was determined by euglycemic hyperinsulinemic clamp tests. 8-Iso-prostaglandin F-2 alpha (8-iso PGF(2 alpha)), an F-2-isoprostane, was measured in the urine as a marker of lipid peroxidation, and highly sensitive C-reactive protein and IL-6 were analyzed in plasma as markers of inflammation. Peripheral insulin sensitivity [mg glucose center dot kg body wt(-1) center dot min(-1) per unit plasma insulin (mU/L) x 100] did not improve when subjects consumed whole-grain products (6.8 +/- 3.0 at baseline and 6.5 +/- 2.7 after 6 wk) or refined products (6.4 +/- 2.9 and 6.9 +/- 3.2, respectively) and there were no differences between the 2 periods. Whole-grain consumption also did not affect 8-iso-PGF(2 alpha) in urine, IL-6 and C-reactive protein in plasma, blood pressure, or serum lipid concentrations. In conclusion, substitution of whole grains (mainly based on milled wheat) for refined-grain products in the habitual daily diet of healthy moderately overweight adults for 6-wk did not affect insulin sensitivity or markers of lipid peroxidation and inflammation.