Cardiovascular Benefits of Wearing Particulate-Filtering Respirators: A Randomized Crossover Trial.
Cardiovascular Benefits of Wearing Particulate-Filtering Respirators: A Randomized Crossover Trial.
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DOI：
10.1289/ehp73
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发表时间：
2017-02
影响因子：
10.4
通讯作者：
Kan H
中科院分区：
文献类型：
--
作者：
Shi J;Lin Z;Chen R;Wang C;Yang C;Cai J;Lin J;Xu X;Ross JA;Zhao Z;Kan H
发展中国家迫切需要采取切实可行的办法，保护个人免受环境颗粒物（PM）的影响。关于佩戴颗粒过滤器对健康有益的证据有限。我们评估了在中国佩戴呼吸机对心血管健康的短期影响。2014年在中国上海的24名健康年轻人中进行了一项随机交叉试验。受试者被随机分为两组，并佩戴颗粒过滤器48小时，间隔3周洗脱。在每次干预的第2个24小时内连续监测心率变异性（HRV）和动态血压（BP）。在每次干预结束时测量循环生物标志物。应用线性混合效应模型来评估佩戴呼吸器对健康结果的影响。在干预期间，空气动力学直径< 2.5 μm的PM（PM2.5）的日均浓度为74.2 μg/m3。与不佩戴呼吸器相比，佩戴呼吸器可使收缩压降低2.7 mmHg [95%置信区间（CI）：0.1，5.2 mmHg]，心率变异性参数增加，包括12.5%。（95%CI：3.8%，21.2%）高频（HF）功率，10.9%（95% CI：1.8%，20.0%），连续差异的均方根为22.1%。（95% CI：3.6%，40.7%）持续时间> 50 msec的正常RR间期与之前正常RR间期（pNN 50）的差异百分比。存在干扰器也与低频（LF）/HF功率比降低7.8%（95% CI：3.5%，12.1%）相关。短期佩戴颗粒过滤器可能会通过改善自主神经功能和降低血压来产生心血管益处。Shi J，Lin Z，Chen R，Wang C，Yang C，Cai J，Lin J，Xu X，Ross JA，Zhao Z，Kan H. 2017.佩戴颗粒过滤呼吸器的心血管益处：一项随机交叉试验。环境健康展望125：175-180; http：dx.doi.org/10.1289/EHP73
Practical approaches to protect individuals from ambient particulate matter (PM) are urgently needed in developing countries. Evidence on the health benefits of wearing particulate-filtering respirators is limited. We evaluated the short-term cardiovascular health effects of wearing respirators in China. A randomized crossover trial was performed in 24 healthy young adults in Shanghai, China in 2014. The subjects were randomized into two groups and wore particulate-filtering respirators for 48 hr alternating with a 3-week washout interval. Heart rate variability (HRV) and ambulatory blood pressure (BP) were continuously monitored during the 2nd 24 hr in each intervention. Circulating biomarkers were measured at the end of each intervention. Linear mixed-effect models were applied to evaluate the effects of wearing respirators on health outcomes. During the intervention periods, the mean daily average concentration of PM with an aerodynamic diameter < 2.5 μm (PM2.5) was 74.2 μg/m3. Compared with the absence of respirators, wearing respirators was associated with a decrease of 2.7 mmHg [95% confidence interval (CI): 0.1, 5.2 mmHg] in systolic BP and increases of HRV parameters, including 12.5% (95% CI: 3.8%, 21.2%) in high frequency (HF) power, 10.9% (95% CI: 1.8%, 20.0%) in the root mean square of the successive differences, and 22.1% (95% CI: 3.6%, 40.7%) in the percentage of normal RR intervals with duration > 50 msec different from the previous normal RR interval (pNN50). The presence of respirators was also associated with a decrease of 7.8% (95% CI: 3.5%, 12.1%) in the ratio of low frequency (LF)/HF power. Short-term wearing of particulate-filtering respirators may produce cardiovascular benefits by improving autonomic nervous function and reducing BP. Shi J, Lin Z, Chen R, Wang C, Yang C, Cai J, Lin J, Xu X, Ross JA, Zhao Z, Kan H. 2017. Cardiovascular benefits of wearing particulate-filtering respirators: a randomized crossover trial. Environ Health Perspect 125:175–180; http://dx.doi.org/10.1289/EHP73