Attenuation of ductus arteriosus intimal thickening in preterm sheep twins compared with singletons
Attenuation of ductus arteriosus intimal thickening in preterm sheep twins compared with singletons
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DOI：
10.1007/s12576-017-0565-5
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发表时间：
2017-11-01
影响因子：
2.3
通讯作者：
Ishikawa, Yoshihiro
中科院分区：
文献类型：
--
作者：
Ito, Satoko;Yokoyama, Utako;Ishikawa, Yoshihiro
早产双胞胎动脉导管未闭（PDA）的发病率高于单胞胎。然而，多胞胎对动脉导管（DA）成熟的影响尚未报道。由于内膜增厚（IT）是DA解剖学闭合所必需的，我们研究了早产双胎和单胎DA的IT发展。从早产胎儿获得的绵羊DA组织进行弹性货车Gieson染色来评估IT。每个DA中的总IT得分是从DA的6个等分部分获得的IT得分的总和，这与单胎的胎龄正相关。早产双胞胎的总IT评分小于单胞胎，但未观察到胎龄、出生体重或性别比的差异。这些数据表明，在绵羊早产双胞胎中，DA的IT发育减弱，这可能影响PDA的高发病率。
Preterm twins have a higher morbidity rate of patent ductus arteriosus (PDA) than do singletons. However, the effect of multiple births on maturation of the ductus arteriosus (DA) has not been reported. Because intimal thickening (IT) is required for DA anatomical closure, we examined IT development in the DA of preterm twins and singletons. Sheep DA tissues obtained from preterm fetuses were subjected to elastica van Gieson staining to evaluate IT. The total IT score in each DA was the sum of the IT scores obtained from six evenly divided parts of the DA, which was positively correlated with gestational ages in singletons. Total IT scores were smaller in preterm twins than in singletons, although no difference in gestational age, birth weight, or gender ratio was observed. These data suggest that IT development of the DA is attenuated in sheep preterm twins, which may affect the higher morbidity of PDA.