Understanding the tumor immune microenvironment (TIME) for effective therapy.
Understanding the tumor immune microenvironment (TIME) for effective therapy.
复制标题
了解肿瘤免疫微环境（TIME）以获得有效治疗。
DOI：
10.1038/s41591-018-0014-x
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发表时间：
2018-05
期刊：
影响因子：
82.9
通讯作者：
Krummel MF
中科院分区：
文献类型：
--
作者：
Binnewies M;Roberts EW;Kersten K;Chan V;Fearon DF;Merad M;Coussens LM;Gabrilovich DI;Ostrand-Rosenberg S;Hedrick CC;Vonderheide RH;Pittet MJ;Jain RK;Zou W;Howcroft TK;Woodhouse EC;Weinberg RA;Krummel MF
免疫疗法的临床成功既令人震惊，同时又令人不满意。无数不同肿瘤类型的患者通过免疫治疗干预已经看到了明显的临床反应；然而，更多的患者在接受同样的治疗时，临床获益很少或根本没有。随着技术的进步，人们对肿瘤微环境免疫背景的复杂性和多样性及其对治疗反应的影响的认识也在不断提高。已经有可能确定对肿瘤起始、反应和治疗有影响的不同免疫环境亚类；通过分析患者肿瘤中存在的肿瘤免疫微环境（TIME）的独特类别和亚类别，可以提高预测和指导免疫治疗反应性的能力，从而揭示新的治疗靶点。
The clinical successes in immunotherapy have been both astounding and at the same time unsatisfactory. Countless patients with varied tumor types have seen pronounced clinical response with immunotherapeutic intervention; however, many more patients have experienced minimal or no clinical benefit when provided the same treatment. As technology has advanced, so has the understanding of the complexity and diversity of the immune context of the tumor microenvironment and its influence on response to therapy. It has been possible to identify different subclasses of immune environment that have an influence on tumor initiation and response and therapy; by parsing the unique classes and subclasses of tumor immune microenvironment (TIME) that exist within a patient’s tumor, the ability to predict and guide immunotherapeutic responsiveness will improve, and new therapeutic targets will be revealed.
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影响因子：
168.9
作者：
Burn, John;Gerdes, Anne-Marie;Macrae, Finlay;Mecklin, Jukka-Pekka;Moeslein, Gabriela;Olschwang, Sylviane;Eccles, Diane;Evans, D. Gareth;Maher, Eamonn R.;Bertario, Lucio;Bisgaard, Marie-Luise;Dunlop, Malcolm G.;Ho, Judy W. C.;Hodgson, Shirley V.;Lindblom, Annika;Lubinski, Jan;Morrison, Patrick J.;Murday, Victoria;Ramesar, Raj;Side, Lucy;Scott, Rodney J.;Thomas, Huw J. W.;Vasen, Hans F.;Barker, Gail;Crawford, Gillian;Elliott, Faye;Movahedi, Mohammad;Pylvanainen, Kirsi;Wijnen, Juul T.;Fodde, Riccardo;Lynch, Henry T.;Mathers, John C.;Bishop, D. Timothy
通讯作者：
Bishop, D. Timothy
影响因子：
50.3
作者：
Di Biase S;Lee C;Brandhorst S;Manes B;Buono R;Cheng CW;Cacciottolo M;Martin-Montalvo A;de Cabo R;Wei M;Morgan TE;Longo VD
通讯作者：
Longo VD
影响因子：
30.5
作者：
Finkin S;Yuan D;Stein I;Taniguchi K;Weber A;Unger K;Browning JL;Goossens N;Nakagawa S;Gunasekaran G;Schwartz ME;Kobayashi M;Kumada H;Berger M;Pappo O;Rajewsky K;Hoshida Y;Karin M;Heikenwalder M;Ben-Neriah Y;Pikarsky E
通讯作者：
Pikarsky E
影响因子：
64.8
作者：
Finisguerra V;Di Conza G;Di Matteo M;Serneels J;Costa S;Thompson AA;Wauters E;Walmsley S;Prenen H;Granot Z;Casazza A;Mazzone M
通讯作者：
Mazzone M
影响因子：
120.7
作者：
Cook, NR;Lee, IM;Buring, JE
通讯作者：
Buring, JE