Contrast-enhanced harmonic endoscopic ultrasonography with time-intensity curve analysis for intraductal papillary mucinous neoplasms of the pancreas
Contrast-enhanced harmonic endoscopic ultrasonography with time-intensity curve analysis for intraductal papillary mucinous neoplasms of the pancreas
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DOI：
10.1055/s-0034-1393563
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发表时间：
2016-01-01
期刊：
影响因子：
9.3
通讯作者：
de Yamamoto, Kazuh
中科院分区：
文献类型：
--
作者：
Yamamoto, Naoki;Kato, Hironari;de Yamamoto, Kazuh
背景和研究目的：导管内乳头状黏液性肿瘤（IPMNs）的术前病理分级诊断是困难的。本研究旨在评价超声造影谐波内镜（CH-EUS）结合时间-强度曲线分析鉴别低、中度异型增生（LGD/IGD）与高度异型增生或浸润癌的准确性（HGD/浸润性癌），并评估时间-强度曲线参数与肿瘤微血管密度之间的相关性。回顾性分析30例IPMN患者（14例LGD/IGD，16例HGD/浸润癌）行CH-EUS检查的时间-强度曲线。比较HGD/浸润癌组和LGD/IGD组的时间-强度曲线参数和壁结节的微血管密度，评价时间-强度曲线参数的诊断准确性。HGD/浸润癌组壁结节的回声强度变化率、回声强度降低率及结节/胰腺实质的对比率均显著高于LGD/IGD组（P
Background and study aims: Preoperative diagnosis of the pathological grade of intraductal papillary mucinous neoplasms (IPMNs) is difficult. This study aimed to evaluate the accuracy of contrast-enhanced harmonic endoscopic ultrasonography (CH-EUS) with time-intensity curve analysis in differentiating between low or intermediate grade dysplasia (LGD/IGD) and high grade dysplasia or invasive carcinoma (HGD/invasive carcinoma) in IPMNs and to assess correlation between the time-intensity curve parameters and tumor microvessel density.Patients and methods: Data from 30 patients with resected IPMNs (14 LGD/IGD, 16 HGD/invasive carcinoma) who underwent CH-EUS with time-intensity curve analysis were evaluated retrospectively. Time-intensity curve parameters and the microvessel density of the mural nodule were compared between the HGD/invasive carcinoma and LGD/IGD groups; the diagnostic accuracy of the time-intensity curve parameters was evaluated.Results: The echo intensity change and echo intensity reduction rate of the mural nodule, and the nodule/pancreatic parenchyma contrast ratio were significantly higher in the HGD/invasive carcinoma group than in the LGD/IGD group (P