Consequences of large interindividual variability for human brain atlases: converging macroscopical imaging and microscopical neuroanatomy.
Consequences of large interindividual variability for human brain atlases: converging macroscopical imaging and microscopical neuroanatomy.
复制标题
人脑图谱个体差异大的后果：宏观成像和微观神经解剖学的融合。
DOI：
10.1007/s00429-005-0042-4
复制
发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Zilles,K
中科院分区：
文献类型：
--
作者：
Uylings,HBM;Rajkowska,G;Sanz-Arigita,E;Amunts,K;Zilles,K
在人脑成像研究中，通常使用Talairach立体定位参考系统来表示脑功能和结构的会聚。在几乎所有的神经影像学报告中，所研究的皮层区域都用Brodmann面积（BA）编号进一步指定。本规范是基于宏观外推从布罗德曼的投影映射到Talairach地图集，而不是一个真实的微观细胞结构的研究。在这篇评论中，我们认为，这样的规范Brodmann地区（S）通过Talairach地图集是不合适的。本文回顾的细胞结构研究表明，即使在校正大脑大小和形状的差异后，初级感觉皮层区（视觉皮层）和异模态联想区（前额叶皮层区）的3-D位置也存在很大的个体间差异。因此，简单地使用Brodmann皮质区来自Talairach地图集可能会导致错误的结果，在规范的相关BA。这反过来又会进一步导致对参与正常功能或特定大脑疾病的大脑系统的错误假设。此外，我们将简要讨论不同的'布罗德曼'命名法，这是在使用的大脑皮层。
In human brain imaging studies, it is common practice to use the Talairach stereotaxic reference system for signifying the convergence of brain function and structure. In nearly all neuroimaging reports, the studied cortical areas are specified further with a Brodmann Area (BA) number. This specification is based upon macroscopic extrapolation from Brodmann’s projection maps into the Talairach atlas rather than upon a real microscopic cytoarchitectonic study. In this review we argue that such a specification of Brodmann area(s) via the Talairach atlas is not appropriate. Cytoarchitectonic studies reviewed in this paper show large interindividual differences in 3-D location of primary sensory cortical areas (visual cortex) as well as heteromodal associational areas (prefrontal cortical areas), even after correction for differences in brain size and shape. Thus, the simple use of Brodmann cortical areas derived from the Talairach atlas can lead to erroneous results in the specification of pertinent BA. This in turn can further lead to wrong hypotheses on brain system(s) involved in normal functions or in specific brain disorders. In addition, we will briefly discuss the different ‘Brodmann’ nomenclatures which are in use for the cerebral cortex.