A Core Outcome Set for Pediatric Critical Care.
A Core Outcome Set for Pediatric Critical Care.
复制标题
DOI：
10.1097/ccm.0000000000004660
复制
发表时间：
2020-12
影响因子：
8.8
通讯作者：
Pediatric Outcomes STudies after PICU (POST-PICU) Investigators of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network and the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN)
中科院分区：
文献类型：
--
作者：
Fink EL;Maddux AB;Pinto N;Sorenson S;Notterman D;Dean JM;Carcillo JA;Berg RA;Zuppa A;Pollack MM;Meert KL;Hall MW;Sapru A;McQuillen PS;Mourani PM;Wessel D;Amey D;Argent A;Brunow de Carvalho W;Butt W;Choong K;Curley MAQ;Del Pilar Arias Lopez M;Demirkol D;Grosskreuz R;Houtrow AJ;Knoester H;Lee JH;Long D;Manning JC;Morrow B;Sankar J;Slomine BS;Smith M;Olson LM;Watson RS;Pediatric Outcomes STudies after PICU (POST-PICU) Investigators of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network and the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN)
越来越多的儿童在危重疾病中幸存下来，但面临残留或新的健康状况的风险。儿科重症监护结果缺乏基于证据和利益相关者推荐的核心结果集。我们的目标是创建一个多国、多方利益相关者推荐的儿科重症监护核心成果集，以纳入临床和研究项目。对 333 名受邀研究、临床和家庭/倡导者利益相关者进行了 2 轮修改后的德尔福电子调查。完成第一轮的利益相关者被邀请参加第二轮。结果得分 > 69%“关键”和 < 15%“不重要”进入第二轮，并考虑写入结果。指导委员会举行了一次虚拟共识会议，以确定最终的组成部分。跨国调查。来自六大洲的利益相关者参与者代表临床医生、研究人员和家庭/倡导者。每轮的总体答复率分别为 75% 和 82%。参与者在第一轮中对 7 个全球领域和 45 个具体结果进行投票，在第二轮中对 6 个全球领域和 30 个具体结果进行投票。使用总体（3 个利益相关者群体组合）结果，共识被定义为得分 > 90%“关键”和 < 15%“不重要”的结果，并包含在最终的 PICU COS 中：4 个全球领域（认知、情感、身体和整体健康）和 4 个具体结果（儿童健康相关）生活质量、疼痛、生存和沟通）。家庭 (n=21) 提出了未达成共识的其他至关重要的结果，这些结果已包含在 PICU COS - 扩展中。 PICU 核心成果集和 PICU COS 扩展是多方利益相关者推荐的临床和研究项目资源，旨在改善患有危重病的儿童及其家人的成果。
More children are surviving critical illness but are at risk of residual or new health conditions. An evidence-informed and stakeholder-recommended core outcome set is lacking for pediatric critical care outcomes. Our objective was to create a multinational, multi-stakeholder-recommended Pediatric Critical Care Core Outcome Set for inclusion in clinical and research programs. A 2-round modified Delphi electronic survey was conducted with 333 invited research, clinical, and family/advocate stakeholders. Stakeholders completing the first round were invited to participate in the second. Outcomes scoring > 69% “critical” and < 15% “not important” advanced to round 2 with write-in outcomes considered. The Steering Committee held a virtual consensus conference to determine the final components. Multinational survey. Stakeholder participants from 6 continents representing clinicians, researchers, and family/advocates. Overall response rates were 75% and 82% for each round. Participants voted on 7 Global Domains and 45 Specific Outcomes in Round 1, and 6 Global Domains and 30 Specific Outcomes in Round 2. Using Overall (3 stakeholder groups combined) results, consensus was defined as outcomes scoring > 90% “critical” and < 15% “not important” and were included in the final PICU COS: 4 Global domains (Cognitive, Emotional, Physical and Overall Health) and 4 Specific outcomes (Child Health-Related Quality of Life, Pain, Survival, and Communication). Families (n=21) suggested additional critically important outcomes that did not meet consensus, which were included in the PICU COS - Extended. The PICU Core Outcome Set and PICU COS-Extended are multi-stakeholder-recommended resources for clinical and research programs that seek to improve outcomes for children with critical illness and their families.