Negative correlation between right prefrontal activity during response inhibition and impulsiveness: A fMRI study
Negative correlation between right prefrontal activity during response inhibition and impulsiveness: A fMRI study
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DOI：
10.1007/s00406-004-0488-z
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发表时间：
2004-08-01
影响因子：
4.7
通讯作者：
Yokota, N
中科院分区：
文献类型：
--
作者：
Asahi, S;Okamoto, Y;Yokota, N
Go/No-Go任务中的行为去抑制被认为与人类的冲动有关。最近的成像研究表明，涉及额叶皮层和其他相关皮层（如顶叶皮层）的不同区域的神经回路与No-Go试验期间的反应抑制有关。本研究的目的是调查在No-Go试验和冲动之间的关联区域大脑激活。17名右利手的健康志愿者参与了这项研究。我们使用功能性磁共振成像来测量Go/No-Go任务期间的大脑激活。采用Barratt冲动性量表第11版（BIS-11）测量冲动性。激活区域包括右侧额中回和顶叶下叶，这与之前的神经影像学研究一致。BIS-11的运动冲动与右侧背外侧前额叶皮层（RDLPFC）的No-Go相关激活呈负相关。我们的研究结果表明，RDLPFC是最敏感的地区，在个人运动冲动的差异，其活动可能是一个指标的个人能力的反应抑制。
Behavioral disinhibition in Go/No-Go task is thought to be associated with impulsiveness in humans. Recent imaging studies showed that neural circuits involving diverse areas of the frontal cortex and other association cortex sites such as the parietal cortex are implicated in the inhibition of response during No-Go trials. The aim of the present study was to investigate the association between regional cerebral activation during No-Go trials and impulsiveness. Seventeen right-handed healthy volunteers participated in the study. We used functional magnetic resonance imaging to measure the brain activation during a Go/No-Go task. The Barratt Impulsiveness Scale, 11(th) version (BIS-11) was used to measure impulsiveness. Activated regions included the right middle frontal gyrus and the inferior parietal lobe, which is consistent with previous neuroimaging studies. A negative correlation was observed between the motor impulsiveness of BIS-11 and No-Go-related activation in the right dorsolateral prefrontal cortex (RDLPFC). Our results suggest that the RDLPFC is the area most sensitive to differences in individual motor impulsiveness and its activity may be an indicator of the individual capacity for response inhibition.