Relationships among tonic and episodic aspects of motivation to eat, gut peptides, and weight before and after bariatric surgery
Relationships among tonic and episodic aspects of motivation to eat, gut peptides, and weight before and after bariatric surgery
复制标题
DOI：
10.1016/j.soard.2012.09.011
复制
发表时间：
2013-09-01
影响因子：
3.1
通讯作者：
Naslund, Erik
中科院分区：
文献类型：
--
作者：
Bryant, Eleanor J.;King, Neil A.;Naslund, Erik
背景：Roux-en-Y胃旁路手术(RYGB)后进食动机、进食行为特征和肠肽之间的相互作用尚不完全清楚。方法：评估12名肥胖(体重指数45+/-1.9 kg/m(2))受试者在RYGB手术前即刻、术后3天、2个月和1年的食欲和激素对固定液体预负荷的反应。在餐后3小时内测量主观食欲和血浆Ghrelin、瘦素、胰岛素和胰升糖素样肽-1(GLP-1)水平。结果：TFEQR18情绪性进食(EE)和无节制进食(UE)自术前至术后1年均有所下降，但认知约束(CR)无明显变化。这些变化与体重的变化无关。此外，主观食欲评分降低，食欲多肽发生改变，有利于厌食反应。术前EE与空腹和曲线下面积(AUC)Ghrelin显著相关，UE与AUC食欲相关，禁食食欲与Ghrelin(空腹和AUC)显著相关。术后1年UE与空腹胰岛素呈正相关，CR与GLP-1呈负相关。UE与主观饥饿感呈正相关，而食欲与Ghrelin呈正相关。结论：肥胖患者在RYGB手术前和术后1年的主观食欲评分、饮食行为特征和食欲多肽之间的关系可能有助于减少暴食倾向(以TFEQR18因子衡量)和体重减轻。(C)2013年皇冠版权，由爱思唯尔公司代表美国新陈代谢和减肥外科学会出版。版权所有。
Background: The interaction between motivation to eat, eating behavior traits, and gut peptides after Roux-en-Y gastric bypass (RYGB) surgery is not fully understood.Methods: Appetite and hormone responses to a fixed liquid preload were assessed in 12 obese (body mass index 45 +/- 1.9 kg/m(2)) participants immediately before and 3 days, 2 months, and 1 year after RYGB surgery. Subjective appetite and plasma levels of ghrelin, leptin, insulin, and glucagon-like peptide-1 (GLP-1) were measured for a 3-hour postprandial period. Eating behavior traits were also measured using the Three Factor Eating Questionnaire 18 (TFEQR18).Results: There was a decrease in TFEQR18 emotional eating (EE) and uncontrolled eating (UE) from presurgery to 1 year postsurgery but no significant change in cognitive restraint (CR). These changes occurred independently of change in weight. In addition, there was a reduction in subjective appetite ratings and alterations in appetite peptides favoring an anorectic response. Presurgery EE was significantly related to fasting and area under the curve (AUC) ghrelin; UE was associated with AUC desire to eat, and there was a significant association between fasting desire to eat and ghrelin (fasting and AUC). One year postsurgery, UE was positively related to fasting insulin, and CR was negatively associated with GLP-1. UE and subjective hunger were positively correlated, while the relationship between desire to eat and ghrelin remained.onclusion: The relationships among subjective appetite ratings, eating behavior traits, and appetite peptides in obese patients both before and at 1 year after RYGB surgery may contribute to the reduction in a propensity to overeat (as measured by TFEQR18 factors) and weight loss. (c) Crown Copyright 2013 Published by Elsevier Inc. on behalf of American Society for Metabolic and Bariatric Surgery. All rights reserved.