PRIMARY EPITHELIAL TUMOR IN RIGHT ATRIUM OF HEART AND INFERIOR VENA-CAVA IN NZR-GD INBRED RATS - PATHOLOGY OF 18 CASES
PRIMARY EPITHELIAL TUMOR IN RIGHT ATRIUM OF HEART AND INFERIOR VENA-CAVA IN NZR-GD INBRED RATS - PATHOLOGY OF 18 CASES
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DOI：
10.1002/path.1711160407
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发表时间：
1975-01-01
影响因子：
7.3
通讯作者：
HURLEY, JV
中科院分区：
文献类型：
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作者：
GOODALL, CM;CHRISTIE, GS;HURLEY, JV
在NZR/Gd近交系白化大鼠中，肿瘤发生在右心房或下腔静脉的比例约为20%。未经处理的动物，无论性别，年龄在1岁以上。肿瘤位于右房壁者15例，位于下腔静脉者3例，均为原发部位。肿瘤生长缓慢，但最终是恶性的。光镜和电子显微镜研究表明，肿瘤是由嵌入在含有梭形细胞和薄壁毛细血管的胶原性结缔组织中的上皮肺泡组成。上皮由扁平到低柱状，常向管腔内分泌粘液物质，有时分泌到周围组织中。这种肿瘤，被建议命名为房腔上皮间皮瘤，非常类似于之前在人类中描述的一种罕见的右心房上皮瘤，使用了不同的名称。在人类的这些肿瘤中存在潜在的胚胎学异常，而NZR/Gd近交系大鼠心脏中高发的病理相似病变的发生应该有助于检验这种罕见心脏肿瘤发生的遗传和发育原因假说。
In NZR/Gd inbred albino rats, tumours occurred in the right atrium or inferior vena cava of approximately 20 per cent. of untreated animals, of both sexes, over the age of 1 yr. The tumours were centred in the wall of the right atrium in 15 cases, and in the inferior vena cava in another three cases; they appeared to be primary in these sites. The tumours were slowly growing, but eventually malignant. Light-and electron-microscopic study showed the tumours were composed of epithelial alveoli imbedded in a collagenous connective tissue containing spindle cells and thin-walled blood capillaries. The epithelium varied from flat to low columnar, and often secreted mucoid material into the lumina, or sometimes into surrounding tissue. This tumour, for which the name atrio-caval epithelial mesothelioma is suggested, very closely resembles a rare epithelial tumour of the right atrium previously described in humans under a variety of names. An underlying embryological anomaly had been postulated in these tumours in humans, and the occurrence of pathologically similar lesions in high incidence in hearts of NZR/Gd inbred rats should help test the hypothesis of genetic and developmental causes in the genesis of this rare cardiac neoplasm.