Mechanisms of venous thrombosis and resolution
Mechanisms of venous thrombosis and resolution
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DOI：
10.1161/atvbaha.108.162289
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发表时间：
2008-03-01
影响因子：
8.7
通讯作者：
Henke, Peter K.
中科院分区：
文献类型：
--
作者：
Wakefield, Thomas W.;Myers, Daniel D.;Henke, Peter K.
静脉血栓栓塞在美国是一个重要的卫生保健问题。在这篇综述中，强调了炎症在静脉血栓形成过程中的独特作用以及纤溶机制异常在血栓形成过程中的潜在作用。炎症不仅影响血栓形成，而且还影响血栓消退和静脉壁重塑，并讨论了这些相互作用。静脉血栓形成的分子和免疫机制及其解决方案的知识应该允许未来的靶向治疗的发展。
Venous thromboembolism is a significant health care problem in the US. In this review, the unique role of inflammation to the venous thrombotic process is emphasized as well as the potential role of abnormalities of fibrinolytic mechanisms to the thrombotic process. Inflammation influences not only thrombogenesis but also thrombus resolution and vein wall remodeling, and these interactions are also discussed. Knowledge of molecular and immunologic mechanisms for venous thrombosis and its resolution should allow for the future development of targeted therapies.