Agminated Flexural Melanocytic Nevi: A Late Sequela of Langerhans Cell Histiocytosis?

Agminated Flexural Melanocytic Nevi: A Late Sequela of Langerhans Cell Histiocytosis?
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弯曲性黑素细胞痣:朗格汉斯细胞组织细胞增多症的晚期后遗症?

DOI:
10.1111/pde.12563
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发表时间:
2015
影响因子:
1.5
通讯作者:
A. Bruckner
A. Bruckner
中科院分区:
医学4区
文献类型:
--
作者:
S. Feldstein;Tracy Funk;John C. Smith;A. Bruckner

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有朗格汉斯细胞组织细胞增生症病史的儿童发生的聚集性弯曲黑素细胞痣是罕见的,被认为是巧合或与全身化疗有关。我们报告了一名11岁的男孩,在缓解LCH,只有局部类固醇治疗,谁提出了几年后,爆发的黑色素细胞痣在双侧腹股沟和腋窝地区。我们推测聚集性弯曲黑素细胞痣是LCH的晚期后遗症,可能是免疫耐受或局部炎症反应所致,而不是巧合。
Agminated flexural melanocytic nevi in children with a history of Langerhans cell histiocytosis (LCH) are rare and thought to be coincidental or related to systemic chemotherapy. We report on an 11‐year‐old boy in remission from LCH, treated with only topical steroids, who presented years later with an eruption of melanocytic nevi in the bilateral inguinal and axillary regions. Rather than coincidence, we hypothesize that agminated flexural melanocytic nevi are a late sequela of LCH, possibly resulting from immune tolerance or a reaction to local inflammation.
Eguchi S. 等人:“Angrotensin II 的细胞内信号传导诱导 VSMC 中 Ser 411 处的 P70S6 激酶磷酸化。”
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