Fc gamma receptor-like hepatitis C virus core protein binds differentially to IgG of discordant Fc (GM) genotypes.
Fc gamma receptor-like hepatitis C virus core protein binds differentially to IgG of discordant Fc (GM) genotypes.
复制标题
Fc γ 受体样丙型肝炎病毒核心蛋白与不一致 Fc (GM) 基因型的 IgG 存在差异性结合。
DOI：
10.1016/j.molimm.2007.03.022
复制
发表时间：
2007
影响因子：
3.6
通讯作者：
Pandey,JanardanP
中科院分区：
文献类型：
--
作者：
Namboodiri,AryanM;Budkowska,Agata;Nietert,PaulJ;Pandey,JanardanP
Immunoglobulin GM allotypes are associated with the outcome of several infections, including hepatitis C virus (HCV) infection, but the underlying mechanisms are not known. HCV employs sophisticated strategies to evade host immunosurveillance. One such strategy might involve the scavenging of the Fcγ domain of the anti-HCV IgG antibodies by its Fcγ receptor-like site formed by HCV core protein, potentially interfering with the Fcγ-mediated host defense mechanisms. We tested the hypothesis that GM allotypes modulate this viral strategy through differential binding to the core protein. Here we show that the absorbance values for binding to the HCV core protein were significantly higher for IgG1 with GM 3 allotype than that for the allelic GM 1,2,17 determinants (p=0.0003). These results provide a mechanistic explanation for the involvement of GM allotypes in the outcome of HCV infection. These findings also shed light on the possible evolutionary selective mechanism that maintains GM polymorphism.
