Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis.
Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis.
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DOI：
10.1038/nature10653
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发表时间：
2011-11-20
期刊：
影响因子：
64.8
通讯作者：
Chawla, Ajay
中科院分区：
文献类型：
--
作者：
Nguyen, Khoa D.;Qiu, Yifu;Cui, Xiaojin;Goh, Y. P. Sharon;Mwangi, Julia;David, Tovo;Mukundan, Lata;Brombacher, Frank;Locksley, Richard M.;Chawla, Ajay
所有主热疗法都利用热生成来维持核心体温，确保在寒冷的环境中发生细胞功能和生理过程。 （BAT）和白脂肪组织（WAT）。尽管它刺激了热基因的表达，例如PPARγ共激活因子1a（PPARGC1A），解偶联蛋白1（UCP1）和酰基-COA合成酶长链族族成员1（ACSL1），但在棕色脂肪细胞中。在此涉及的所有涉及的细胞类型都不确定。热暴露迅速促进脂肪组织巨噬细胞的替代激活，秘密的儿茶酚胺在蝙蝠中诱导热基因表达，而在WAT中脂肪解析造成了脂肪症。动员和能量消耗，都是巨噬细胞的。替代激活的巨噬细胞在重要的哺乳动物应力反应的编排中的作用，即对冷的反应。
All homeotherms utilize thermogenesis to maintain core body temperature, ensuring that cellular functions and physiologic processes can ensue in cold environments. In the prevailing model, when the hypothalamus senses cold temperatures, it triggers sympathetic discharge, resulting in the release of noradrenaline in brown adipose tissue (BAT) and white adipose tissue (WAT). Acting via the β3-adrenergic receptors, noradrenaline induces lipolysis in white adipocytes, whereas it stimulates the expression of thermogenic genes, such as PPARγ coactivator 1a (Ppargc1a), uncoupling protein 1 (Ucp1), and acyl-CoA synthetase long-chain family member 1 (Acsl1), in brown adipocytes. However, the precise nature of all the cell types involved in this efferent loop is not well established. Here we report an unexpected requirement for the interleukin 4 (IL4)-stimulated program of alternative macrophage activation in adaptive thermogenesis. Cold exposure rapidly promoted alternative activation of adipose tissue macrophages, which secrete catecholamines to induce thermogenic gene expression in BAT and lipolysis in WAT. Absence of alternatively activated macrophages impaired metabolic adaptations to cold, whereas administration of IL4 increased thermogenic gene expression, fatty acid mobilization, and energy expenditure, all in a macrophage-dependent manner. We have thus discovered a surprising role for alternatively activated macrophages in the orchestration of an important mammalian stress response, the response to cold.
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影响因子：
64.5
作者：
Puigserver, P;Wu, ZD;Spiegelman, BM
通讯作者：
Spiegelman, BM
影响因子：
56.9
作者：
Haemmerle, G;Lass, A;Zechner, R
通讯作者：
Zechner, R
影响因子：
64.8
作者：
Enerback, S;Jacobsson, A;Kozak, LP
通讯作者：
Kozak, LP
影响因子：
64.8
作者：
ZHOU, QY;QUAIFE, CJ;PALMITER, RD
通讯作者：
PALMITER, RD
DOI：
10.1146/annurev-pathol-011110-130138
发表时间：
2011
期刊：
Annual review of pathology
影响因子：
--
作者：
Odegaard JI;Chawla A
通讯作者：
Chawla A