A RECEPTOR-MEDIATED IMMUNE-RESPONSE USING SYNTHETIC GLYCOCONJUGATES
A RECEPTOR-MEDIATED IMMUNE-RESPONSE USING SYNTHETIC GLYCOCONJUGATES
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DOI：
10.1021/ja00040a009
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发表时间：
1992-07-01
影响因子：
15
通讯作者：
BEDNARSKI, MD
中科院分区：
文献类型：
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作者：
BERTOZZI, CR;BEDNARSKI, MD
细菌病原体的抗体识别对于激活补体和巨噬细胞介导的过程很重要。然而，许多细菌抗原会发生遗传变异以避免抗体识别。合成糖缀合物可以通过 1 型菌毛甘露糖特异性受体将抗体引导至大肠杆菌细胞。受体靶向抗体激活补体和巨噬细胞介导的过程，导致细胞死亡。因此，可以利用细菌细胞表面受体来赋予生物体抗原性。
Antibody recognition of bacterial pathogens is important for activating complement and macrophage-mediated processes. Many bacterial antigens, however, undergo genetic variation to avoid antibody recognition. A synthetic glycoconjugate can direct antibodies to E. coli cells via their type 1 pili mannose-specific receptors. The receptor targeted antibodies activate both complement and macrophage-mediated processes that result in cell death. Bacterial cell-surface receptors can therefore be exploited to confer antigenicity onto the organism.