Bacterial endophthalmitis after cataract extraction. II. Incidence in 36,000 consecutive operations with special reference to preoperative topical antibiotics.
Bacterial endophthalmitis after cataract extraction. II. Incidence in 36,000 consecutive operations with special reference to preoperative topical antibiotics.
复制标题
白内障摘除术后细菌性眼内炎。
DOI：
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发表时间：
1973
期刊：
影响因子：
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通讯作者：
A. Mangiaracine
中科院分区：
文献类型：
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作者：
H. F. Allen;A. Mangiaracine
21年来，36000例连续白内障手术的记录显示有31例感染，总感染率为0.086%。1964年报告的第一批2万例感染率为0.11%。分析最近16,000例关于术前预防性局部抗生素的病例，发现一个明显显著的变量。0.5%硫酸新霉素与其他两种抗生素联合使用时，每1000例感染6例（发生率0.6%）。以0.4%氯霉素代替新霉素时，1.5万例手术中有3例感染（发生率为1 / 5000,0.02%）。氯霉素与其他抗生素联合使用时，26307例手术中发生6例感染（发生率为1 / 4384,0.022%）。当考虑到假定与某些感染相关的其他因素时，对使用和不使用氯霉素的比率进行调整，结果显示，包括氯霉素在内的联合用药的有利因素为13倍。
Records of 36,000 consecutive cataract operations in 21 years reveal 31 infections—an overall rate of 0.086%. The first 20,000 cases, reported in 1964, had an infection rate of 0.11%. Analysis of the most recent 16,000 cases regarding preoperative prophylactic topical antibiotics reveals an apparently significant variable. When neomycin sulfate 0.5% was used with two other antibiotics, there were six infections in 1,000 cases (rate, 0.6%). When chloramphenicol 0.4% was substituted for neomycin, there were three infections in 15,000 operations (rate, one in 5,000 or 0.02%). In combination when chloramphenicol was used with other antibiotics, six infections occurred in 26,307 operations (rate, one in 4,384 or 0.022%. When other factors presumptively related to certain infections are considered, adjustment of the rates with and without chloramphenicol reveals a factor of 13 times in favor of combinations including chloramphenicol.