Relating Intrinsic Low-Frequency BOLD Cortical Oscillations to Cognition in Schizophrenia
Relating Intrinsic Low-Frequency BOLD Cortical Oscillations to Cognition in Schizophrenia
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DOI：
10.1038/npp.2015.119
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发表时间：
2015-11-01
影响因子：
7.6
通讯作者：
Mathalon, Daniel H.
中科院分区：
文献类型：
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作者：
Fryer, Susanna L.;Roach, Brian J.;Mathalon, Daniel H.
低频波动（ALFF）的幅度在血氧水平依赖（BOLD）信号在静息态fMRI反映了本地低频BOLD振荡的幅度，而不是区域间的连接。ALFF对认知的研究很有意义，因为自发的内在脑活动的波动与健康人的任务诱发的脑反应有关，甚至可能限制。据报道，精神分裂症患者的ALFF较低，但这些降低的认知相关性仍不清楚。在这里，我们评估ALFF和注意力和工作记忆之间的关系，以建立内在的BOLD振荡功率改变与精神分裂症的特定认知障碍的功能相关性。作为多位点FBIRN研究的一部分，从精神分裂症受试者（SZ; n=168）和健康对照组（HC; n=166）中收集静息状态fMRI数据。体素分数ALFF（fALFF）是一种标准化的ALFF测量方法，对SZ和HC的持续注意力和工作记忆的神经心理学测量进行回归，以确定显示组间共同斜率或组间斜率差异的区域（所有结果P
The amplitude of low-frequency fluctuations (ALFF) in the blood oxygenation level-dependent (BOLD) signal during resting-state fMRI reflects the magnitude of local low-frequency BOLD oscillations, rather than interregional connectivity. ALFF is of interest to studies of cognition because fluctuations in spontaneous intrinsic brain activity relate to, and possibly even constrain, task-evoked brain responses in healthy people. Lower ALFF has been reported in schizophrenia, but the cognitive correlates of these reductions remain unknown. Here, we assess relationships between ALFF and attention and working memory in order to establish the functional relevance of intrinsic BOLD oscillatory power alterations with respect to specific cognitive impairments in schizophrenia. As part of the multisite FBIRN study, resting-state fMRI data were collected from schizophrenia subjects (SZ; n=168) and healthy controls (HC; n=166). Voxelwise fractional ALFF (fALFF), a normalized ALFF measure, was regressed on neuropsychological measures of sustained attention and working memory in SZ and HC to identify regions showing either common slopes across groups or slope differences between groups (all findings P