Implications of mitochondrial DNA mutations and mitochondrial dysfunction in tumorigenesis.
Implications of mitochondrial DNA mutations and mitochondrial dysfunction in tumorigenesis.
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DOI：
10.1038/cr.2009.69
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发表时间：
2009-07
期刊：
影响因子：
44.1
通讯作者：
Bai Y
中科院分区：
文献类型：
--
作者：
Lu J;Sharma LK;Bai Y
长期以来，线粒体功能障碍引起的氧化磷酸化的改变一直被认为与肿瘤的发生有关。线粒体最近被证明在调节细胞程序性死亡和细胞增殖方面起着重要作用。此外，在各种癌细胞中也发现了线粒体DNA(MtDNA)突变。然而，这些线粒体DNA突变在肿瘤发生中的作用在很大程度上仍不清楚。本文就线粒体的基本遗传学、线粒体DNA突变以及由此导致的与癌症相关的线粒体功能障碍进行综述。并对线粒体DNA突变、线粒体功能障碍、肿瘤发生的分子机制进行了讨论。
Alterations in oxidative phosphorylation resulting from mitochondrial dysfunction have long been hypothesized to be involved in tumorigenesis. Mitochondria have recently been shown to play an important role in regulating both programmed cell death and cell proliferation. Furthermore, mitochondrial DNA (mtDNA) mutations have been found in various cancer cells. However, the role of these mtDNA mutations in tumorigenesis remains largely unknown. This review focuses on basic mitochondrial genetics, mtDNA mutations and consequential mitochondrial dysfunction associated with cancer. The potential molecular mechanisms, mediating the pathogenesis from mtDNA mutations and mitochondrial dysfunction to tumorigenesis are also discussed.