Use of Tl-201 to detect untreated pediatric Hodgkin disease.
Use of Tl-201 to detect untreated pediatric Hodgkin disease.
复制标题
使用 Tl-201 检测未经治疗的小儿霍奇金病。
作者：
Barry D. Fletcher;W. M. Kauffman;Sue C. Kaste;H. Winer;Lei Fang;Gang Chen;M. Hudson
目的
评价铊-201放射性核素显像在描述小儿新诊断霍奇金病相关的膈上淋巴结病中的作用。
材料和方法
在33名连续患者中获得了胸部和颈部的铊-201和镓-67扫描。纵隔、颈部、锁骨上和腋窝淋巴结活动由独立评估者评估，结果以盲法与胸部计算机断层扫描（CT）结果进行比较。
结果
镓和铊扫描在CT定义的纵隔肿块的描述中表现出相似的准确性。Kappa统计量表明与CT结果中度至高度一致。同样，铊和镓扫描在描述纵隔外淋巴结病方面的准确性之间没有统计学显著差异。
结论
铊淋巴结造影术是描述儿童霍奇金淋巴结病未经治疗的有效方法。系列铊研究可能提供一种替代镓扫描监测治疗反应。
PURPOSE
To evaluate the usefulness of thallium-201 scintigrams in depiction of supradiaphragmatic lymphadenopathy associated with newly diagnosed Hodgkin disease in pediatric patients.
MATERIALS AND METHODS
Thallium-201 and gallium-67 scans of the chest and neck were obtained in 33 consecutive patients. Mediastinal, cervical, supraclavicular, and axillary lymph node activity was evaluated by independent raters, and results were compared in a blinded fashion with those on chest computed tomographic (CT) scans.
RESULTS
Gallium and thallium scans demonstrated similar accuracy in depiction of CT-defined mediastinal masses. The kappa statistic indicated moderate to strong agreement with CT results. Similarly, there was no statistically significant difference between the accuracy of thallium and gallium scans in depiction of extramediastinal lymphadenopathy.
CONCLUSION
Thallium scintigraphy is effective for depiction of lymphadenopathy in pediatric patients with untreated Hodgkin disease. Serial thallium studies may provide an alternative to gallium scans in monitoring response to treatment.