MODELS OF TUMOR HOST INTERACTION AS COMPETING POPULATIONS - IMPLICATIONS FOR TUMOR BIOLOGY AND TREATMENT
MODELS OF TUMOR HOST INTERACTION AS COMPETING POPULATIONS - IMPLICATIONS FOR TUMOR BIOLOGY AND TREATMENT
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DOI：
10.1006/jtbi.1995.0212
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发表时间：
1995-10-21
影响因子：
2
通讯作者：
GATENBY, RA
中科院分区：
文献类型：
--
作者：
GATENBY, RA
种群生态学数学模型不是将肿瘤作为转化个体的孤立集合进行研究，而是将其作为恶性细胞和正常细胞相互作用的动态社会的一部分。这一方法研究了肿瘤细胞的小克隆能够取代先前稳定的大得多的正常细胞群体的机制，尽管后者具有数量优势和宿主反应的抑制效应。这些模型用关键的数学参数定义了一系列不同的稳定平衡，这些参数控制着肿瘤-宿主竞争的不同阶段的结果--这些参数可以与细胞的生理特性相关联。当肿瘤被视为一个相互作用的肿瘤和正常人群的网络时，可以发展一个统一的假设，允许根据转化细胞在这个网络中对肿瘤发生的特定贡献来理解转化细胞的不同但不一致的属性。它预测了肿瘤存活和侵袭所必需的基因变化的一般序列，并证明了在不同的肿瘤模型中发现的明显不同的特性在功能上是相同的。这篇论文提出了新的治疗模式，需要根据肿瘤采用的策略来分类酸治疗，而不是传统的细胞类型和起源器官的标准。(C)1995年学术出版社有限公司
Population ecology mathematical models examine tumors not as an isolated collection of transformed individuals but as part of a dynamic society of interacting malignant and normal cells. This approach investigates the mechanisms by which a small clone of neoplastic cells is able to replace the much larger and previously stable population of normal cells, despite the numerical advantage of the latter and the inhibitory effects of the host response. The models define a sequence of different stable equilibria with critical mathematical parameters which control the outcome of different stages of the neoplasm-host competition-parameters which can be correlated with cellular physiologic properties. When neoplasm is viewed as a network of interacting tumor and normal populations, a unifying hypothesis can be developed that allows the diverse but inconsistent properties of transformed cells to be understood according to their specific contributions to tumorigenesis within this network. It predicts general sequences of genetic changes necessary for tumor survival and invasion and demonstrates that apparently disparate properties found in different tumor models can be functionally equivalent. The paper proposes novel modes of therapy requiring classification acid treatment of tumors according to the strategies they employ, rather than the traditional criteria of cell type and organ of origin. (C) 1995 Academic Press Limited