Pulmonary Vascular and Right Ventricular Reserve in Patients With Normalized Resting Hemodynamics After Pulmonary Endarterectomy
Pulmonary Vascular and Right Ventricular Reserve in Patients With Normalized Resting Hemodynamics After Pulmonary Endarterectomy
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DOI：
10.1161/jaha.114.001602
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发表时间：
2015-03-01
影响因子：
5.4
通讯作者：
Heidbuchel, Hein
中科院分区：
文献类型：
--
作者：
Claessen, Guido;La Gerche, Andre;Heidbuchel, Hein
背景-慢性血栓栓塞性肺动脉高压（CTEPH）患者在肺动脉内膜切除术（PEA）后，平均肺动脉压（mPAP）正常化，但并不总能恢复正常的运动能力。我们评估了右心室功能，它与搏动性和阻力性后负荷的相互作用，以及西地那非在这些患者运动过程中的作用。
Background-Patients with normalized mean pulmonary artery pressure (mPAP) after pulmonary endarterectomy (PEA) for chronic thromboembolic pulmonary hypertension (CTEPH) do not always regain normal exercise capacity. We evaluated right ventricular function, its interaction with both pulsatile and resistive afterload, and the effect of sildenafil during exercise in these patients.Methods and Results-Fourteen healthy controls, 15 CTEPH patients, and 7 patients with normalized resting mPAP (