Sleep stages and EEG power spectrum in relation to acoustical stimulus arousal threshold in the rat.
Sleep stages and EEG power spectrum in relation to acoustical stimulus arousal threshold in the rat.
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DOI：
10.1093/sleep/16.5.467
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发表时间：
1993-08
期刊：
影响因子：
5.6
通讯作者：
D. Neckelmann;R. Ursin
中科院分区：
文献类型：
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作者：
D. Neckelmann;R. Ursin
本研究旨在从功能上验证先前描述的视觉睡眠评分标准，该标准与声刺激唤醒阈值有关。进一步的目的是探讨脑电图（EEG）功率谱与声刺激阈值之间的关系。在对声音刺激（1000 hz正弦音，每秒增加1.5 dB，持续45秒）习以为常后，分析声刺激开始后的唤醒潜伏期值。唤醒是根据脑电图和肌电图（EMG）标准确定的。睡眠阶段的影响显著，慢波睡眠2 （SWS-2）唤醒阈值高于慢波睡眠1 （SWS-1）、快速眼动（REM）睡眠和过渡型睡眠。这表明，将大鼠非快速眼动（NREM）睡眠细分为SWS-1和SWS-2在该范式下具有功能有效性。一天中的时间也有显著的影响，在8小时的记录期的最后2小时（光照期的第9和第10小时）唤醒阈值较低。此外，脑电功率密度对脑电信号的影响显著。高次幂的唤醒阈值较低的唤醒阈值高。结果与delta活动是NREM睡眠深度的一个指标的概念是一致的。
This study was designed to functionally validate earlier described criteria for visual sleep scoring with respect to acoustical stimulus threshold for arousal. A further objective was to explore the relation between electroencephalographic (EEG) power spectrum and acoustical stimulus threshold for arousal. After habituation to an acoustical stimulus (a 1,000-Hz sine tone, increasing 1.5 dB per second for 45 seconds), values for latency to arousal after acoustical stimulus onset were analyzed. Arousal was determined based on EEG and electromyographic (EMG) criteria. There was a significant effect of sleep stage, with slow wave sleep 2 (SWS-2) having higher arousal threshold than slow wave sleep 1 (SWS-1), rapid eye movement (REM) sleep and transition type sleep. This indicates that the subdivision of nonrapid eye movement (NREM) sleep in the rat into SWS-1 and SWS-2 had functional validity in this paradigm. Time of day also had a significant effect, with lower arousal threshold in the last 2 hours (ninth and tenth hour of the light period) of the 8-hour registration period. Furthermore, there was a significant effect of EEG delta power density. Epochs with high delta power had increased arousal threshold relative to epochs with low arousal threshold. The results were consistent with the notion that delta activity is an indicator of depth within NREM sleep.