A handheld electronic device with the potential to detect lung cancer biomarkers from exhaled breath
A handheld electronic device with the potential to detect lung cancer biomarkers from exhaled breath
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DOI：
10.1007/s10544-022-00638-8
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发表时间：
2022-12-01
影响因子：
2.8
通讯作者：
Sun, Nian-Xiang
中科院分区：
文献类型：
--
作者：
Emam, Shadi;Nasrollahpour, Mehdi;Sun, Nian-Xiang
肺癌是美国癌症死亡的主要原因。在最常见的癌症中，它的5年生存率最低，因此，早期诊断是提高生存率的关键。本文提出了一种新的手持电子设备来检测呼气中的9种肺癌生物标志物。在铬修饰的硅衬底上沉积了一层薄薄的石墨烯和普鲁士蓝薄膜，制成了电化学气体传感器。通过分子印迹聚合物(MIP)形成分析物的选择性结合。随后的聚合和去除分析物在传感器的顶部产生了一层导电聚合物，其中包含对目标分子具有选择性的分子印迹空腔。传感器的测试范围为万亿分之一(Ppt)浓度，而传感器的电阻随着传感器通过电阻变化与分析物发生反应而被监测。对戊烷传感器的选择性也进行了测试。设计了一块印刷电路板来测量每个传感器的电阻，并通过蓝牙将数据发送到智能手机中开发的应用程序。这种手持设备有可能在不久的将来被用作一种诊断方法。
Lung cancer is the leading cause of cancer death in the United States. It has the lowest 5-year survival rate among the most common cancers and therefore, early diagnosis is critical to improve the survival rate. In this paper, a new handheld electronic device is proposed to detect nine lung cancer biomarkers in the exhaled breath. An electrochemical gas sensor was produced through deposition of a thin layer of graphene and Prussian blue on a chromium-modified silicon substrate. Selective binding of the analyte was formed by molecular imprinting polymer (MIP). Subsequent polymerization and removal of the analyte yielded a layer of a conductive polymer on top of the sensor containing molecularly imprinted cavities selective for the target molecule. The sensors were tested over 1-20 parts per trillion (ppt) level of concentration while the sensor resistance has been monitored as the sensors react to the analyte by resistance change. Pentane sensor was also tested for selectivity. A printed circuit board was designed to measure the resistance of each sensor and send the data to a developed application in smartphone through Bluetooth. This handheld device has the potential to be used as a diagnostic method in the near future.