RESPONSE CRITERIA FOR PHASE-II STUDIES OF SUPRATENTORIAL MALIGNANT GLIOMA
RESPONSE CRITERIA FOR PHASE-II STUDIES OF SUPRATENTORIAL MALIGNANT GLIOMA
复制标题
DOI：
10.1200/jco.1990.8.7.1277
复制
发表时间：
1990-07-01
影响因子：
45.3
通讯作者：
CAIRNCROSS, JG
中科院分区：
文献类型：
--
作者：
MACDONALD, DR;CASCINO, TL;CAIRNCROSS, JG
我们建议幕上恶性胶质瘤的II期研究采用“新的”反应标准，并赞成与肿瘤内科相似的严格标准，但需进行重要修改。提出了四种缓解类别：完全缓解（CR）、部分缓解（PR）、疾病稳定（SD）和疾病进展（PD）。该方案中的缓解基于增强计算机断层扫描（CT）或磁共振成像（MRI）扫描中肿瘤大小的主要变化。根据类固醇的使用和神经系统的发现来解释扫描的变化。我们提倡谨慎选择患者，强调反应评估中的陷阱，并提出指导方针，以尽量减少对反应的误解。
We suggest "new" response criteria for phase II studies of supratentorial malignant glioma and favor rigorous criteria similar to those in medical oncology, with important modifications. Four response categories are proposed: complete response (CR), partial response (PR), stable disease (SD), and progressive disease (PD). Response in this scheme is based on major changes in tumor size on the enhanced computed tomographic (CT) or magnetic resonance imaging (MRI) scan. Scan changes are interpreted in light of steroid use and neurologic findings. We advocate careful patient selection, emphasize pitfalls in the assessment of response, and suggest guidelines to minimize misinterpretations of response.