Influence of aging on the sleep rebound induced by immobilization stress in the rat
Influence of aging on the sleep rebound induced by immobilization stress in the rat
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DOI：
10.1016/j.brainres.2010.03.087
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发表时间：
2010-06
期刊：
影响因子：
2.9
通讯作者：
A. Descamps;R. Cespuglio
中科院分区：
文献类型：
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作者：
A. Descamps;R. Cespuglio
现已知道，在短时间(1h)的束缚应激(IS)后，成年大鼠表现出显著的快速眼动(REM)睡眠反弹。在这项研究中，我们研究了老年动物中的这种现象。我们发现，与年轻的动物相比，受到IS的老年大鼠在限制后没有表现出睡眠反弹。然而，老年大鼠和成年大鼠的血浆皮质酮和促肾上腺皮质激素(ACTH1-39)水平相似。弓状核的促肾上腺皮质激素样中间叶肽(CLIP或ACTH18-39)系统可能通过桥脑投射(HP)参与快速眼动睡眠的发生，在老年和青年大鼠中也没有差异。因此，在老年动物中观察到的缺乏REM睡眠反弹是独立于HPA(下丘脑-垂体-肾上腺)和HP AXE活动的。这种因果损害可能存在于脑桥背侧被盖的REM睡眠执行结构。
It is now known that after an immobilization stress (IS) of short duration (1h), adult rats exhibit a significant rapid eye movement (REM) sleep rebound. In this study, we examined this phenomenon in aged animals. We found that aged rats subjected to an IS did not show a sleep rebound after the restraint, in contrast to younger animals. Plasma corticosterone and corticotrophin (ACTH1–39) levels were, however, similar in aged and adult rats. The corticotrophin-like intermediate lobe peptide (CLIP or ACTH18–39) system of the arcuate nucleus, suggested to be involved in REM sleep genesis by way of pontine projections (HP: the hypothalamo–pontine axis), was also not different between aged and young rats. The lack of REM sleep rebound observed in aged animals is thus independent of the HPA (hypothalamo–pituitary–adrenal) and HP axe activities. The causal impairments might reside in REM sleep executive structures of the dorsal pontine tegmentum.