Disrupted Neural Synchrony Mediates the Relationship between White Matter Integrity and Cognitive Performance in Older Adults
Disrupted Neural Synchrony Mediates the Relationship between White Matter Integrity and Cognitive Performance in Older Adults
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DOI：
10.1093/cercor/bhaa141
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发表时间：
2020-10-01
期刊：
影响因子：
3.7
通讯作者：
Courtney, S. M.
中科院分区：
文献类型：
--
作者：
Hinault, T.;Kraut, M.;Courtney, S. M.
我们的主要目标是确定白质完整性对老年人大脑区域之间的动态耦合和认知表现的个体变异性的影响。当参与者执行一项专门设计用来进行工作记忆和抑制过程的任务时，记录脑电，并评估功能活动、结构完整性和认知表现之间的关联。我们发现，白质微结构完整性和认知功能与衰老之间的联系是由时变的阿尔法和伽马锁相值调节的。具体地说，在老年人中，更好地保存额枕下束可以更快地对额叶下回和枕叶之间的阿尔法和伽马远程锁相值进行任务相关的调制，并降低枕叶的局部相位-幅度耦合，这反过来又会推动更好的认知控制性能。我们的结果有助于描述白质微结构的个体变异性在正常衰老过程中的动态同步性和认知表现中的作用。
Our main goal was to determine the influence of white matter integrity on the dynamic coupling between brain regions and the individual variability of cognitive performance in older adults. Electroencephalography was recorded while participants performed a task specifically designed to engage working memory and inhibitory processes, and the associations among functional activity, structural integrity, and cognitive performance were assessed. We found that the association between white matter microstructural integrity and cognitive functioning with aging is mediated by time-varying alpha and gamma phase-locking value. Specifically, better preservation of the inferior fronto-occipital fasciculus in older individuals drives faster task-related modulations of alpha and gamma long-range phase-locking value between the inferior frontal gyrus and occipital lobe and lower local phase-amplitude coupling in occipital lobes, which in turn drives better cognitive control performance. Our results help delineate the role of individual variability of white matter microstructure in dynamic synchrony and cognitive performance during normal aging.