Neuromagnetic activity in the somatosensory cortices of children with cerebral palsy
Neuromagnetic activity in the somatosensory cortices of children with cerebral palsy
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DOI：
10.1016/j.neulet.2010.11.053
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发表时间：
2011-02-18
影响因子：
2.5
通讯作者：
Wilson, Tony W.
中科院分区：
文献类型：
--
作者：
Kurz, Max J.;Wilson, Tony W.
脑瘫（CP）儿童的触觉、本体感受和动觉意识发生了改变。这些感觉障碍似乎与躯体感觉皮层的异常组织有关。到目前为止，神经磁反应的躯体感觉皮层代表脚还没有调查痉挛型双瘫CP儿童。在这项研究中，我们使用脑磁图（MEG）来评估典型发育儿童和粗大运动功能分类评分为III-IV的痉挛性双瘫CP儿童的足部刺激引起的最早体感反应的皮质差异。所有参与者都接受了单侧胫神经刺激的每只脚作为全脑MEG数据采集。初级体感皮层反应建模使用等效电流偶极子为每只脚。本研究的结果首次表明，痉挛型双瘫CP患儿代表足部的体感皮层的激活减少，但不是潜伏的。(C)2010爱思唯尔爱尔兰有限公司版权所有。
Children with cerebral palsy (CP) have altered tactile, proprioceptive and kinesthetic awareness. These sensory impairments appear to be related to an aberrant organization of the somatosensory cortex. To date, the neuromagnetic responses of somatosensory cortices representing the foot have not been investigated in children with spastic diplegic CP. In this investigation, we used magnetoencephalography (MEG) to evaluate cortical differences in the earliest somatosensory responses elicited by foot stimulation in typically developing children and those with spastic diplegic CP who have a Gross Motor Function Classification Score of III-IV. All participants underwent unilateral tibial nerve stimulation of each foot as whole brain MEG data were acquired. Primary somatosensory cortical responses were modeled using an equivalent current dipole for each foot. The results presented in this study are the first to show that activation of the somatosensory cortices representing the foot in children with spastic diplegic CP is diminished, but not latent. (C) 2010 Elsevier Ireland Ltd. All rights reserved.