LDH ISOENZYMES IN CSF IN THE DIAGNOSIS OF NEONATAL BRAIN-DAMAGE
LDH ISOENZYMES IN CSF IN THE DIAGNOSIS OF NEONATAL BRAIN-DAMAGE
复制标题
DOI：
10.1111/j.1600-0404.1986.tb04621.x
复制
发表时间：
1986-07-01
影响因子：
3.5
通讯作者：
ROCHE, MC
中科院分区：
文献类型：
--
作者：
FERNANDEZ, F;QUERO, J;ROCHE, MC
本文对25例窒息新生儿出生后24小时内脑脊液乳酸脱氢酶同工酶进行了测定。这些婴儿接受了平均15.2个月的临床和发育检查。脑脊髓LDH 2（MH3）和LDH 3（M2H2）同工酶的平均值显着高于窒息的婴儿谁死于缺氧缺血性脑病或谁生存，但有神经系统后遗症，比他们在窒息的婴儿谁生存，并在后续研究中正常。因此，作者得出结论，脑脊液中乳酸脱氢酶同工酶谱在评估缺氧性脑损伤时可能有价值。
Lactate dehydrogenase isoenzymes in cerebrospinal fluid were measured during the first 24 h of life in 25 asphyctic neonates. The infants were subjected to clinical and developmental examinations for a mean follow-up period of 15.2 months. The mean values for cerebrospinal LDH2(MH3) and LDH3(M2H2) isoenzymes were significantly higher in asphyctic infants who died from hypoxic-ischemic encephalopathy or who survived but suffered neurologic sequelae, than they were in those asphyctic infants who survived and were normal in the follow-up studies. Therefore, the authors conclude that the lactate dehydrogenase isoenzyme pattern in cerebrospinal fluid may be of value when assessing anoxic brain damage.