Hippocampal CRE-mediated gene expression is required for contextual memory formation
Hippocampal CRE-mediated gene expression is required for contextual memory formation
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DOI：
10.1038/nn951
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发表时间：
2002-11-01
影响因子：
25
通讯作者：
Storm, DR
中科院分区：
文献类型：
--
作者：
Athos, J;Impey, S;Storm, DR
与背景长期记忆（LTM）形成相关的分子事件之一是环AMP反应元件（CRE）介导的转录的诱导。在这里，我们报告说，激活NMDA受体和细胞外信号调节激酶（ERK）是必要的刺激CREE介导的转录在上下文恐惧条件反射。此外，我们发现，在学习过程中抑制CRE-regulated转录会阻断LTM，这表明这种转录活性对记忆形成至关重要。
One of the molecular events associated with contextual long-term memory (LTM) formation is the induction of cyclic AMP response element (CRE)-mediated transcription. Here we report that activation of NMDA receptors and of extracellular signal–regulated kinase (ERK) were necessary for stimulation of CRE-mediated transcription during contextual fear conditioning. In addition, we found that inhibition of CRE-regulated transcription during learning blocked LTM, which indicates that this transcriptional activity is critical for memory formation.