Plasticity in the projection from the anterior thalamic nuclei to the anterior cingulate cortex in the rat in vivo:: Paired-pulse facilitation, long-term potentiation and short-term depression
Plasticity in the projection from the anterior thalamic nuclei to the anterior cingulate cortex in the rat in vivo:: Paired-pulse facilitation, long-term potentiation and short-term depression
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DOI：
10.1016/s0306-4522(01)00554-1
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发表时间：
2002-01-01
期刊：
影响因子：
3.3
通讯作者：
O'Mara, SM
中科院分区：
文献类型：
--
作者：
Gemmell, C;O'Mara, SM
一些关于啮齿动物导航系统的神经生理学和计算理论表明，额叶和丘脑的不同皮层共享信息，因此突触强度发生变化。我们首次研究了从丘脑前核到前扣带皮层的三种形式的突触可塑性：我们证明了这种投射能够表达成对脉冲促进、长期增强和短期抑制。此外，输入/输出曲线显示，高频刺激后，在所有刺激强度下，场兴奋性突触后电位振幅均增加。这些发现为我们理解这一重要通路的突触可塑性提供了重要信息，这一重要通路被广泛假设在啮齿动物的记忆和空间表征中发挥重要作用。(C) 2002年由Elsevier Science Ltd代表IBRO出版。
Several neurophysiological and computational theories of the rodent navigational system suggest that the differing cortices of the frontal lobe and thalamus share information and therefore undergo changes in synaptic strength. We examine here for the first time three forms of synaptic plasticity in the projection from the anterior thalamic nuclei to the anterior cingulate cortex: we demonstrate that this projection is capable of expressing paired-pulse facilitation, long-term potentiation, and short-term depression. Furthermore, input/output curves show that field excitatory post-synaptic potential amplitude increased at all stimulus intensities following high-frequency stimulation. These findings add important information to our understanding of synaptic plasticity in this important pathway, which has been widely hypothesized to play important roles in memory and spatial representation in the rodent. (C) 2002 Published by Elsevier Science Ltd on behalf of IBRO.