Comparison of the effect of oligonol, a new lychee fruit-derived low molecular form of polyphenol, and epigallocatechin-3-gallate on lipolysis in rat primary adipocytes
Comparison of the effect of oligonol, a new lychee fruit-derived low molecular form of polyphenol, and epigallocatechin-3-gallate on lipolysis in rat primary adipocytes
复制标题
比较寡酚（一种源自荔枝果实的新型低分子多酚形式）和表没食子儿茶素-3-没食子酸酯对大鼠原代脂肪细胞脂肪分解的影响
作者：
Ogasawara;J.;Kitadate;K.;Nishioka;H.;Fujii;H.;Sakurai;T.;Kizaki;T.;Izawa;T.;Ishida;H. & Ohno;H.
一些多酚已被证明对防止哺乳动物体内脂肪的积累有益。本文报道，与单独添加茶(−)-表没食子儿茶素- 3 -没食子酸酯（EGCG）相比，添加寡聚醇（一种从荔枝果实中提取的低分子形式的多酚混合物）对初级脂肪细胞的脂肪分解有更大的影响，并伴有细胞外信号相关激酶1/2 （ERK1/2）的激活显著增加。然而，尽管与未处理的对照细胞相比，低聚醇和EGCG显著增加了MEK1/2和HO - 1的磷酸化水平，但在ERK1/2上游分子有丝分裂原活化蛋白激酶1/2 （MEK1/2）的磷酸化水平和ERK1/2下游分子血红素加氧酶1 （HO - 1）的水平在低聚醇和EGCG之间都没有显著改变。这些结果表明，与单独的EGCG相比，含有低聚醇的混合多酚对ERK1/2的协同直接作用在低聚醇的更大的脂溶反应中起着关键作用。版权所有©2010 John Wiley & Sons， Ltd
Several polyphenols have been shown to be beneficial in preventing the accumulation of body fat in mammals. This paper reports that adding oligonol, a lychee fruit‐derived low‐molecular form of polyphenol mixture, has a greater effect on lipolysis in primary adipocytes compared with tea (−)‐epigallocatechin‐3‐gallate (EGCG) alone, accompanied by a significant increase in activation of extracellular signalling‐related kinase 1/2 (ERK1/2). However, neither phosphorylation of mitogen‐activated protein kinase 1/2 (MEK1/2), a molecule upstream of ERK1/2, nor the level of heme oxygenase‐1 (HO‐1), a molecule downstream of ERK1/2 was significantly changed between oligonol and EGCG, although the addition of oligonol and EGCG significantly increased the levels of phosphorylated MEK1/2 and HO‐1 compared with the non‐treated control cells. These results suggest that the coordinated direct effect of mixed polyphenol, which comprises oligonol, on ERK1/2 plays a key role in a greater lipolytic response to oligonol than EGCG alone. Copyright © 2010 John Wiley & Sons, Ltd.