Randomized controlled trial of weight loss versus usual care on telomere length in women with breast cancer: the lifestyle, exercise, and nutrition (LEAN) study
Randomized controlled trial of weight loss versus usual care on telomere length in women with breast cancer: the lifestyle, exercise, and nutrition (LEAN) study
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DOI：
10.1007/s10549-018-4895-7
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发表时间：
2018-11-01
影响因子：
3.8
通讯作者：
Irwin, Melinda L.
中科院分区：
文献类型：
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作者：
Sanft, Tara;Usiskin, Ilana;Irwin, Melinda L.
目的一些研究表明端粒缩短可能与乳腺癌风险和死亡率增加有关。肥胖还与乳腺癌风险和死亡率增加有关。很少有研究检查超重或肥胖乳腺癌幸存者端粒长度的变化。本研究的目的是检测6个月的饮食和运动减肥干预与常规护理对乳腺癌生存者端粒长度的影响。方法151名体重指数（BMI）25 kg/m2的乳腺癌生存者被随机分为6个月减肥干预组（n=93）和常规护理组（n=58）。在基线和6个月时测量空腹血样、身高、体重、体力活动和饮食。通过对血沉棕黄层提取的基因组DNA进行定量聚合酶链反应（qPCR）测量相对端粒长度（RTL）。平均基线至6个月的变化进行了比较组间（意向治疗）使用广义估计equations.ResultsComplete端粒数据可在125名参与者。女性年龄为588岁，BMI为33.0 +/-6.2 kg/m2，诊断时间为2.9 +/-2.5年; 90%是非西班牙裔白色人，76%患有0/I期乳腺癌。6个月后，随机分配到减肥组的女性有3%的端粒延长，而常规护理组有5%的端粒缩短（p=0.12）。在0/I期女性中，干预组经历了7%的端粒延长，而常规护理组缩短了8%（p=0.01）。没有干预效果，观察妇女与阶段II/III breast cancer.Conclusion p id= Par 4我们的研究结果表明，减肥干预阶段0和1乳腺癌幸存者可能会导致端粒延长，相比，缩短在他们通常的护理同行。
PurposeSome studies suggest that telomere shortening may be associated with increased breast cancer risk and mortality. Obesity is also associated with increased breast cancer risk and mortality. Few studies have examined changes in telomere length in overweight or obese breast cancer survivors. The purpose of our study was to examine the effect of a 6-month diet- and exercise-induced weight loss intervention versus usual care on telomere length in breast cancer survivors.Methods151 breast cancer survivors with body mass index (BMI)25kg/m(2) were randomly assigned to a 6-month weight loss intervention (n=93) or to usual care (n=58). Fasting blood samples, height, weight, physical activity, and diet were measured at baseline and 6-months. Relative telomere length (RTL) was measured by quantitative-polymerase chain reaction (qPCR) done on buffy coat-extracted genomic DNA. Mean baseline to 6-month changes were compared between groups (intention-to-treat) using generalized estimating equations.ResultsComplete telomere data were available in 125 participants. Women were 588 years, with BMI 33.0 +/- 6.2kg/m(2) and were 2.9 +/- 2.5years from diagnosis; 90% were non-Hispanic white, and 76% had stage 0/I breast cancer. After 6 months, women randomized to weight loss had 3% telomere lengthening compared to 5% shortening in the usual care group (p=0.12). Among women with stage 0/I, the intervention group experienced 7% telomere lengthening compared to 8% shortening in the usual care group (p=0.01). No intervention effect was observed in women with stage II/III breast cancer.Conclusion p id=Par4 Our findings suggest a weight loss intervention in stage 0 and 1 breast cancer survivors may lead to telomere lengthening, compared to a shortening in their usual care counterparts.