Identification of mast cell progenitor cells in the airways of individuals with allergic asthma.
Identification of mast cell progenitor cells in the airways of individuals with allergic asthma.
复制标题
过敏性哮喘患者气道中肥大细胞祖细胞的鉴定。
DOI：
10.1111/all.15498
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发表时间：
2023
期刊：
影响因子：
12.4
通讯作者：
Hallstrand,TealS
中科院分区：
文献类型：
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作者：
Murphy,RyanC;Chow,Yu-Hua;Lai,Ying;Al-Shaikhly,Taha;Petroni,DanielH;Black,Michele;Hamerman,JessicaA;Lacy-Hulbert,Adam;Piliponsky,AdrianM;Hallstrand,TealS
肥大细胞 (MC) 是神秘的先天免疫细胞，通常作为效应细胞与哮喘有关，但最近被确定为 2 型 (T2) 细胞因子和哮喘气道炎症调节因子的关键来源 (1)。 MC 是气道壁中的稀有细胞群，主要位于健康个体的上皮下间隙，但在哮喘个体中转移到上皮区室 (2)。尽管它们在哮喘发病机制中很重要，但这种向上皮细胞运输的病因尚不清楚。小鼠命运图谱研究已确定 MCs
Mast cells (MCs) are enigmatic innate immune cells that have classically been implicated in asthma as effector cells but more recently have been identified as key sources of type 2 (T2) cytokines and regulators of airway inflammation in asthma (1). MCs are a rare cell population in the airway wall, primarily located in the subepithelial space of healthy individuals but are shifted to the epithelial compartment in individuals with asthma (2). Despite their importance in asthma pathogenesis, the etiology of this trafficking to the epithelium is not well understood. Fate mapping studies in mice have identified MCs as