Molluscum contagiosum with CD30+ cell infiltration in a patient with mycosis fungoides.
Molluscum contagiosum with CD30+ cell infiltration in a patient with mycosis fungoides.
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蕈样肉芽肿患者的传染性软疣伴有 CD30 细胞浸润。
DOI：
10.1097/dad.0000000000000056
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Hashimoto T
中科院分区：
文献类型：
--
作者：
Ohata C;Fukuda S;Hashikawa K;Ishii N;Hamada T;Nakama T;Furumura M;Tsuruta D;Ohshima K;Hashimoto T
然而，停用NBUVB后，皮肤病变加重。两年后，患者全身出现相对界限不清的红色至棕色鳞片状MF斑。此外，躯干和四肢出现多个5 mm大小的粉红色鲑鱼色丘疹，无MF病变（图2A）。一些丘疹呈脐状（图2B）。实验室检查除可溶性IL-2受体水平（673 U/mL）轻度升高外，无异常发现。MF斑活检组织学显示真皮上层弥漫性淋巴细胞浸润，无明显水肿，表皮内淋巴细胞聚集灶。这些淋巴细胞CD 3和CD 4阳性，而CD 20或CD 30阴性。偶见CD 8+淋巴细胞，丘疹活检组织学显示增生的角化细胞形成肿瘤岛，
However, after discontinuation of NBUVB, the skin lesions exacerbated. Two years later, the patient showed relatively ill-demarcated red to brown scaly macules of MF on the entire body. In addition, multiple pink salmon-colored papules of 5 mm in size developed on the trunk and extremities, sparing MF lesions (Fig. 2A). Some papules were umbilicated (Fig. 2B). Laboratory tests revealed no abnormal findings, except for slightly elevated level of soluble IL-2 receptor (673 U/mL).Histopathology of biopsy from MF macule revealed diffuse infiltrates of lymphocytes without apparent atypia in the upper dermis, with foci of accumulated lymphocytes within the epidermis. These lymphocytes were positive for CD3 and CD4, but negative for CD20 or CD30. Occasional CD8+ lymphocytes were also found. Histopathology of biopsy from papules revealed tumorous islands of proliferating keratinocytes with eosinophilic molluscum inclusion bodies in the