Higher Blood Pressure Associated With Higher Cognition and Functionality Among Centenarians in Australia
Higher Blood Pressure Associated With Higher Cognition and Functionality Among Centenarians in Australia
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DOI：
10.1038/ajh.2010.236
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发表时间：
2011-03-01
影响因子：
3.2
通讯作者：
Kay-Lambkin, Frances
中科院分区：
文献类型：
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作者：
Richmond, Robyn;Law, Jenaleen;Kay-Lambkin, Frances
本研究的目的是检测澳大利亚百岁老人的血压（BP）和胆固醇水平，并比较这些生物学参数与认知和功能状态之间的关系。（Omron Healthcare，墨尔本，澳大利亚）和LDX Cholestech分析仪（Inverness Medical，圣地亚哥，加利福尼亚州）。还获得了病史。认知和功能状态分别采用简易精神状态检查量表（MMSE）和Katz日常生活活动独立性指数（Katz ADL）进行评估。根据WHO标准（>= 140/90 mm Hg），1%的患者患有高血压。然而，38%的百岁老人患有高血压，定义为患有高血压的医学诊断，和/或正在服用抗高血压药物，和/或血压测量值>= 140/90 mm Hg。平均值为：收缩压= 130 mm Hg（90 - 182 mm Hg），舒张压= 70 mm Hg（44-98 mm Hg），脉压（PP）= 60 mm Hg（20-130 mm Hg）。仅在8%的参与者中检测到高胆固醇血症。高血压与高胆固醇血症风险增加无关。收缩压（SBP）低和PP较窄与MMSE评分较低相关。高收缩压和更广泛的PP与更好的功能status.CONCLUSIONSCentenarians有一个非常低的患病率高血压和高胆固醇相比，一般人群。在我们的样本中，心血管疾病的风险因素与痴呆症的风险因素之间似乎存在反比关系。老年人的血压和健康之间似乎存在复杂的相互作用。
BACKGROUNDThe objective of this study was to examine blood pressure (BP) and cholesterol levels among centenarians in Australia, and to compare the relationship between these biological parameters with cognitive and functional status.METHODSWe performed BP (n = 142) and cholesterol (n = 67) measurements using the Omron automated sphygmomanometer (Omron Healthcare, Melbourne, Australia) and the LDX Cholestech Analyzer (Inverness Medical, San Diego, CA), respectively. A medical history was also obtained. Cognitive and functional statuses were assessed using the Mini-Mental State Examination (MMSE) and Katz Index of Independence in Activities of Daily Living (Katz ADL), respectively.RESULTSAverage age of participants was 101.1 years. Hypertension was demonstrated in 1% according to the WHO criterion (>= 140/90 mm Hg). However, 38% of centenarians were hypertensive, defined as having a medical diagnosis of hypertension, and/or being on antihypertensive medications, and/or having a BP measurement >= 140/90 mm Hg. Mean values were: systolic = 130 mm Hg (90182 mm Hg), diastolic = 70 mm Hg (44-98 mm Hg), and pulse pressure (PP) = 60 mm Hg (20-130 mm Hg). Hypercholesterolaemia was only detected in 8% of participants. Hypertension was not associated with increased risk of hypercholesterolaemia. Low systolic BP (SBP) and narrower PP was associated with lower MMSE scores. High SBP and wider PP was associated with better functional status.CONCLUSIONSCentenarians have a very low prevalence of high BP and high cholesterol compared with the general population. There seems to be an inverse relationship between the risk factors for cardiovascular disease vs. the risk factors for dementia in our sample. There appears to be a complex interaction between BP and health in old age.