Five new alkaloids from Coptidis Rhizoma-Euodiae Fructus couple and their cytotoxic activities against gastrointestinal cancer cells
Five new alkaloids from Coptidis Rhizoma-Euodiae Fructus couple and their cytotoxic activities against gastrointestinal cancer cells
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DOI：
10.1016/j.fitote.2013.12.016
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发表时间：
2014-03-01
期刊：
影响因子：
3.4
通讯作者：
Yang, Xiu-Wei
中科院分区：
文献类型：
--
作者：
Qian, Ping;Yang, Xiu-Wei
A new indoloquinazoline alkaloid, 10-methoxywuchuyuamide 1(1), three new benzylisoquinoline alkaloids, named as coptichic aldehyde (2), coptichine (3) and 13-carboxaldehyde-8-oxocoptisine (4), and a new isoindoline alkaloid, named as coptichinamide (5), together with two known alkaloids, wuchuyuamide I (6) and 8-oxocoptisine (7) were isolated from the Coptidis Rhizoma-Euodiae Fructus couple. Their chemical structures were determined by extensive spectroscopic analyses, including IR. UV, EI-MS, HRESI-MS, 1D and 2D NMR data (H-1 NMR, C-13 NMR, H-1-H-1 COSY, HSQC and HMBC). Cytotoxicities of the isolated alkaloids against NCI-N87 and Caco-2 cell lines were evaluated. Four benzylisoquinoline alkaloids 2-4 and 7 showed inhibitory activities against NCI-N87 cell with IC50 values range from 8.92 to 35.98 mu M. The alkaloid 3 was a new antiproliferation compound against NCI-N87 cells. The results provided valuable information for further investigation of alkaloid 3 as a chemopreventive agent. (C) 2013 Published by Elsevier B.V.
