Metabokines in the regulation of systemic energy metabolism
Metabokines in the regulation of systemic energy metabolism
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DOI：
10.1016/j.coph.2022.102286
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发表时间：
2022-09-19
影响因子：
4
通讯作者：
Roberts, Lee D.
中科院分区：
文献类型：
--
作者：
MacCannell, Amanda DV.;Roberts, Lee D.
新陈代谢由涉及代谢物的维持生命的化学反应组成。历史上，代谢物被定义为新陈代谢的中间产物或最终产物，并被认为是代谢过程改变的被动参与者。然而，最近的研究重新定义了我们如何看待新陈代谢。越来越多的证据表明代谢物具有介导细胞信号传导和器官间串扰、调节局部代谢和全身生理学的功能。这些生物活性代谢信号被称为代谢因子。代谢因子调节跨多个组织的多种能量代谢途径，包括脂肪酸0-氧化、线粒体氧化磷酸化、脂解、糖酵解和糖异生。人们越来越有动力去发现新的代谢因子信号轴，以更好地了解这些信号轴在代谢疾病中如何受到干扰，并确定它们作为治疗靶点的效用。
Metabolism consists of life-sustaining chemical reactions involving metabolites. Historically, metabolites were defined as the intermediates or end products of metabolism and considered to be passive participants changed by metabolic processes. However, recent research has redefined how we view metabolism. There is emerging evidence of metabolites which function to mediate cellular signalling and interorgan crosstalk, regulating local metabolism and systemic physiology. These bioactive metabolite signals have been termed metabokines. Metabokines regulate diverse energy metabolism pathways across multiple tissues, including fatty acid 0-oxidation, mitochondrial oxidative phosphorylation, lipolysis, glycolysis and gluconeogenesis. There is increasing impetus to uncover novel metabokine signalling axes to better understand how these may be perturbed in metabolic diseases and determine their utility as therapeutic targets.