Functional evolution of the yeast protein interaction network
Functional evolution of the yeast protein interaction network
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DOI：
10.1093/molbev/msh085
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发表时间：
2004-07-01
影响因子：
10.7
通讯作者：
Ouzounis, CA
中科院分区：
文献类型：
--
作者：
Kunin, V;Pereira-Leal, JB;Ouzounis, CA
蛋白质相互作用是大多数生物过程的核心。我们通过在进化树上绘制蛋白质的起源图，研究了酿酒酵母蛋白质相互作用网络的出现动力学。我们证明，进化阶段的特征是新兴蛋白质的不同连接性水平。我们发现，连接最紧密的蛋白质组可以追溯到真核生物的辐射，而更古老的前真核细胞蛋白质组联系较少。我们表明，功能类具有不同的平均连通性水平，并且这些功能类的出现时间与观察到的进化中的连通性变化是平行的。我们将这些发现作为证据，证明功能的进化可能是整个进化过程中连接性差异的原因。我们认为，理解产生无标度蛋白质相互作用网络的机制，以及可能的其他生物网络，需要考虑蛋白质的功能。
Protein interactions are central to most biological processes. We investigated the dynamics of emergence of the protein interaction network of Saccharomyces cerevisiae by mapping origins of proteins on an evolutionary tree. We demonstrate that evolutionary periods are characterized by distinct connectivity levels of the emerging proteins. We found that the most-connected group of proteins dates to the eukaryotic radiation, and the more ancient group of pre-eukaryotic proteins is less connected. We show that functional classes have different average connectivity levels and that the time of emergence of these functional classes parallels the observed connectivity variation in evolution. We take these findings as evidence that the evolution of function might be the reason for the differences in connectivity throughout evolutionary time. We propose that the understanding of the mechanisms that generate the scale-free protein interaction network, and possibly other biological networks, requires consideration of protein function.